Please use this identifier to cite or link to this item:
|Title:||Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group||Authors:||Yeoh, A.E.-J.
|Issue Date:||2010||Citation:||Yeoh, A.E.-J., Lu, Y., Chan, J.Y.-S., Kham, S.K.-Y., Quah, T.C., Chan, Y.H., Ariffin, H. (2010). Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group. Leukemia Research 34 (3) : 276-283. ScholarBank@NUS Repository. https://doi.org/10.1016/j.leukres.2009.07.003||Abstract:||To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3′-TYMS -6 bp/-6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. © 2009 Elsevier Ltd.||Source Title:||Leukemia Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/25622||ISSN:||01452126||DOI:||10.1016/j.leukres.2009.07.003|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 13, 2019
WEB OF SCIENCETM
checked on Jun 6, 2019
checked on May 24, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.