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Title: Correlation between MR imaging-derived nasopharyngeal carcinoma tumor volume and TNM system
Authors: Chong, V.F.H. 
Zhou, J.-Y.
Chan, K.-L.
Khoo, J.B.K.
Huang, J.
Keywords: Magnetic resonance tumor volume measurement
Nasopharyngeal carcinoma
TNM stage
Issue Date: 2006
Citation: Chong, V.F.H., Zhou, J.-Y., Chan, K.-L., Khoo, J.B.K., Huang, J. (2006). Correlation between MR imaging-derived nasopharyngeal carcinoma tumor volume and TNM system. International Journal of Radiation Oncology Biology Physics 64 (1) : 72-76. ScholarBank@NUS Repository.
Abstract: Purpose: To measure nasopharyngeal carcinoma tumor volume based on magnetic resonance images using a validated semiautomated measurement methodology and correlate tumor volume with TNM T classification. Methods and Materials: The study population consisted of 206 consecutive nasopharyngeal carcinoma patients who had magnetic resonance imaging staging scans. Tumor volume was measured using a semisupervised knowledge-based fuzzy clustering algorithm. Patients were divided into 4 groups according to TNM T classification. The difference in tumor volumes among the various TNM T-classification groups was examined. Results: The mean tumor volume in each T-classification group is as follows: T1, 8.6 mL ± 5.0 (standard deviation [SD]); T2, 18.1 mL ± 8.1 (SD); T3, 25.8 mL ± 14.1 (SD); and T4, 36.2 mL ± 18.9 (SD). The mean tumor volume increased significantly with advancing T classification (p < 0.0001). Tumor volume in a more advanced T group was significantly larger than that in an adjacent early T group (p < 0.01). Conclusion: Validated magnetic resonance imaging-based tumor volume shows positive correlation between tumor volume and advancing T-classification groups. It may be possible to incorporate tumor volume as an additional prognostic factor into the existing TNM system. © 2006 Elsevier Inc.
Source Title: International Journal of Radiation Oncology Biology Physics
ISSN: 03603016
DOI: 10.1016/j.ijrobp.2005.06.027
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