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|Title:||Polymer Drug Conjugation for New Concept Chemotherapy||Authors:||CHAW SU YIN||Keywords:||Prodrug, Polymer drug conjugation, Nanomedicine, Biodegradable polymers, Drug Delivery, Cancer nanotechnology||Issue Date:||20-Jan-2011||Citation:||CHAW SU YIN (2011-01-20). Polymer Drug Conjugation for New Concept Chemotherapy. ScholarBank@NUS Repository.||Abstract:||This research developed a novel prodrug conjugation of Docetaxel (DTX) to d-a-tocopheryl polyethylene glycol succinate (TPGS) in an attempt to eliminate the use of the toxic adjuvant in the current formulation, Taxotere®. TPGS-DTX conjugate was prepared by a two step synthesis and was characterized by 1H NMR and GPC to ensure that conjugation has taken place. In vitro cytotoxicity of TPGS-DTX conjugate was evaluated by MTT assay against MCF-7 breast cancer cell lines. From the IC50 values, the conjugate was found to be 30.9% and 98.6% more effective when cultured with MCF-7 cells for 48 and 72 h respectively in comparison with Taxotere®. In addition, in vivo pharmacokinetics studies showed that the t1/2 of TPGS-DTX was found to be 23-fold longer than that for Taxotere® and the total area-under-curve for TPGS-DTX was 8.6-fold larger than that of Taxotere®, indicating that the prodrug formulation has higher therapeutic effect than Taxotere®.||URI:||http://scholarbank.nus.edu.sg/handle/10635/25442|
|Appears in Collections:||Master's Theses (Open)|
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