Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.intimp.2008.07.019
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dc.titleActivation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L.
dc.contributor.authorChen, Z.
dc.contributor.authorKwong, Huat Tan B.
dc.contributor.authorChan, S.H.
dc.date.accessioned2011-08-05T09:00:25Z
dc.date.available2011-08-05T09:00:25Z
dc.date.issued2008
dc.identifier.citationChen, Z., Kwong, Huat Tan B., Chan, S.H. (2008). Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L.. International Immunopharmacology 8 (12) : 1663-1671. ScholarBank@NUS Repository. https://doi.org/10.1016/j.intimp.2008.07.019
dc.identifier.issn15675769
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25383
dc.description.abstractT lymphocytes play central roles in adaptive immunity. Lycium barbarum L. (L. barbarum), also known as wolfberry, is a Chinese herbal medicine with various biological activities, such as enhancing immunity, protecting liver damage, and reducing the side effects of chemotherapy and radiotherapy. Here, we report that polysaccharide-protein complex from L. barbarum (LBP) is able to activate T cells. LBP was isolated from L. barbarum and separated to five homogenous fractions, designated LBPF1, LBPF2, LBPF3, LBPF4, and LBPF5. We found that LBP, LBPF4, and LBPF5 significantly stimulated mouse splenocyte proliferation. The proliferation proved to be of T cells, but not B cells. Cell cycle profile analysis indicated that LBP, LBPF4, and LBPF5 markedly reduced sub-G1 cells. LBP, LBPF4, and LBPF5 could activate transcription factors NFAT and AP-1, prompt CD25 expression, and induce IL-2 and IFN-γ gene transcription and protein secretion. LBP (i.p. or p.o.) significantly induced T cell proliferation. Our results suggest that activation of T lymphocytes by LBP may contribute to one of its immuno-enhancement functions. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.intimp.2008.07.019
dc.sourceScopus
dc.subjectCD25
dc.subjectCytokine
dc.subjectLycium barbarum polysaccharide-protein complex
dc.subjectT lymphocytes
dc.subjectTranscription factor
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.contributor.departmentWHO IMMUNOLOGY RESEARCH & TRAINING CTR
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.intimp.2008.07.019
dc.description.sourcetitleInternational Immunopharmacology
dc.description.volume8
dc.description.issue12
dc.description.page1663-1671
dc.description.codenIINMB
dc.identifier.isiut000260805100010
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