Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.humpath.2006.01.002
DC FieldValue
dc.titleRenal cell apoptosis and proliferation may be linked to nuclear factor-κB activation and expression of inducible nitric oxide synthase in patients with lupus nephritis
dc.contributor.authorZheng, L.
dc.contributor.authorI-Hong, Hsu S.
dc.contributor.authorSinniah, R.
dc.date.accessioned2011-08-03T01:47:28Z
dc.date.available2011-08-03T01:47:28Z
dc.date.issued2006
dc.identifier.citationZheng, L., I-Hong, Hsu S., Sinniah, R. (2006). Renal cell apoptosis and proliferation may be linked to nuclear factor-κB activation and expression of inducible nitric oxide synthase in patients with lupus nephritis. Human Pathology 37 (6) : 637-647. ScholarBank@NUS Repository. https://doi.org/10.1016/j.humpath.2006.01.002
dc.identifier.issn00468177
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25274
dc.description.abstractThe mechanism of renal cell apoptosis involves transcriptional activation of the inducible nitric oxide synthase (iNOS) gene by nuclear factor (NF)-κB. The role of apoptosis in mediating tubulointerstitial injury in human lupus nephritis (LN) remains unclear. We examined the relationship between alterations in NF-κB activation and iNOS expression levels and the degree of apoptosis in both glomerular and tubulointerstitial compartments of subjects with LN. Studies were done in renal biopsies from 49 patients with LN and 10 normal kidney tissues. Apoptotic and proliferating cells were identified by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling and staining with anti-proliferating cell nuclear antigen antibody, respectively. Nuclear factor-κB and iNOS expression was examined by Southwestern histochemistry and immunohistochemistry, respectively. Glomerular cell apoptosis and proliferation increased concomitantly in LN. Glomerular apoptosis correlated with the activity index, the degree of proliferation, and the level of glomerular overexpression of iNOS and activated NF-κB in LN. Tubular cell apoptosis correlated with the activity and chronicity indices, the degree of tubular atrophy, and decline in renal function at the time of biopsy. Tubular expression of iNOS and activated NF-κB correlated with tubular cell proliferation in LN. Nuclear factor-κB activation accompanied overexpression of iNOS in both glomerular and tubulointerstitium compartments in LN. Apoptosis of renal cells associated with NF-κB activation and iNOS overexpression may play an important role in mediating chronic renal injury, especially tubulointerstitial lesions that may manifest clinically as progressive renal insufficiency. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.humpath.2006.01.002
dc.sourceScopus
dc.subjectApoptosis
dc.subjectInducible nitric oxide synthase
dc.subjectLupus nephritis
dc.subjectNuclear factor-κB
dc.typeArticle
dc.contributor.departmentORTHOPAEDIC SURGERY
dc.description.doi10.1016/j.humpath.2006.01.002
dc.description.sourcetitleHuman Pathology
dc.description.volume37
dc.description.issue6
dc.description.page637-647
dc.identifier.isiut000238241300001
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

29
checked on Feb 21, 2020

WEB OF SCIENCETM
Citations

31
checked on Feb 14, 2020

Page view(s)

193
checked on Feb 19, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.