Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.addr.2010.02.005
DC FieldValue
dc.titleCell-delivery therapeutics for liver regeneration
dc.contributor.authorZhang, W.
dc.contributor.authorChang, S.
dc.contributor.authorJia, R.
dc.contributor.authorShen, S.
dc.contributor.authorYu, H.
dc.contributor.authorTucker-Kellogg, L.
dc.contributor.authorVenkatraman, L.
dc.contributor.authorLu, Y.
dc.contributor.authorWhite, J.K.
dc.contributor.authorBhowmick, S.S.
dc.contributor.authorDewey, C.F.
dc.contributor.authorNarmada, B.C.
dc.contributor.authorTan, N.
dc.date.accessioned2011-08-01T03:06:36Z
dc.date.available2011-08-01T03:06:36Z
dc.date.issued2010
dc.identifier.citationZhang, W., Chang, S., Jia, R., Shen, S., Yu, H., Tucker-Kellogg, L., Venkatraman, L., Lu, Y., White, J.K., Bhowmick, S.S., Dewey, C.F., Narmada, B.C., Tan, N. (2010). Cell-delivery therapeutics for liver regeneration. Advanced Drug Delivery Reviews 62 (7-8) : 814-826. ScholarBank@NUS Repository. https://doi.org/10.1016/j.addr.2010.02.005
dc.identifier.issn0169409X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25194
dc.description.abstractFor acute, chronic, or hereditary diseases of the liver, cell transplantation therapies can stimulate liver regeneration or serve as a bridge until liver transplantation can be performed. Recently, fetal hepatocytes, stem cells, liver progenitor cells, or other primitive and proliferative cell types have been employed for cell transplantation therapies, in an effort to improve the survival, proliferation, and engraftment of the transplanted cells. Reviewing earlier studies, which achieved success by transplanting mature hepatocytes, we propose that there is a switch-like regulation of liver regeneration that changes state according to a stimulus threshold of extracellular influences such as cytokines, matrices and neighboring cells. Important determinants of a successful clinical outcome include sufficient quantities and functional levels of the transplanted cells (even for short periods to alter the environment), rather than just engraftment levels or survival durations of the exogenously transplanted cells. The relative importance of these determining factors will impact future choices of cell sources, delivery vehicles, and sites of cell transplantation to stimulate liver regeneration for patients with severe liver diseases. © 2010 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.addr.2010.02.005
dc.sourceScopus
dc.subjectCell transplantation
dc.subjectDelivery vehicles
dc.subjectEncapsulation
dc.subjectHepatocytes
dc.subjectLiver regeneration
dc.subjectScaffolds
dc.subjectStem cells
dc.subjectSystems Biology
dc.subjectXenogenic cells
dc.typeReview
dc.contributor.departmentPHYSIOLOGY
dc.contributor.departmentCOMPUTER SCIENCE
dc.contributor.departmentSINGAPORE-MIT ALLIANCE
dc.description.doi10.1016/j.addr.2010.02.005
dc.description.sourcetitleAdvanced Drug Delivery Reviews
dc.description.volume62
dc.description.issue7-8
dc.description.page814-826
dc.identifier.isiut000279967500012
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

36
checked on Nov 21, 2022

WEB OF SCIENCETM
Citations

27
checked on Nov 21, 2022

Page view(s)

440
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.