Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.gene.2005.08.022
DC Field | Value | |
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dc.title | Comparative genomics of the human and Fugu voltage-gated calcium channel α1-subunit gene family reveals greater diversity in Fugu | |
dc.contributor.author | Wong, E. | |
dc.contributor.author | Soong, T.W. | |
dc.contributor.author | Yu, W.-P. | |
dc.contributor.author | Yap, W.H. | |
dc.contributor.author | Venkatesh, B. | |
dc.date.accessioned | 2011-08-01T03:05:13Z | |
dc.date.available | 2011-08-01T03:05:13Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Wong, E., Soong, T.W., Yu, W.-P., Yap, W.H., Venkatesh, B. (2006). Comparative genomics of the human and Fugu voltage-gated calcium channel α1-subunit gene family reveals greater diversity in Fugu. Gene 366 (1) : 117-127. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gene.2005.08.022 | |
dc.identifier.issn | 03781119 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/25122 | |
dc.description.abstract | Extensive search for the orthologs of 10 human voltage-gated calcium channel (VGCC) α1-subunit genes in the Fugu genome sequence revealed 21 α1-subunit genes in the compact genome of Fugu. Subtype classification of the identified Fugu α1 orthologs based on phylogenetic analysis, genomic organization and sequence comparison of the most divergent II/III loop and the C-terminal regions of the α1-subunits indicated extra copies of α1S-, α1D-, α1F-, α1A-, α1E-, α1H- and α1G-subunit genes. Phylogenetic analysis reveals that this is likely due to fish lineage specific α1-subunit subtype duplication. Sequence comparison shows that many of the structural features characteristic of VGCC and specific channel subtypes are also present in the Fugu α1-subunits. All the Fugu α1-subunits showed similar expression profile to that of the mammalian α1-subunits except for Fugu α1S, α1A, α1B and α1H which have a more widespread tissue distribution. These results indicate that Fugu, a lower vertebrate, has more extensive channel heterogeneity compared to human. © 2005 Elsevier B.V. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.gene.2005.08.022 | |
dc.source | Scopus | |
dc.subject | Conserved synteny | |
dc.subject | Gene duplication | |
dc.subject | Phylogenetic analysis | |
dc.subject | Tissue distribution | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1016/j.gene.2005.08.022 | |
dc.description.sourcetitle | Gene | |
dc.description.volume | 366 | |
dc.description.issue | 1 | |
dc.description.page | 117-127 | |
dc.identifier.isiut | 000236365100014 | |
Appears in Collections: | Staff Publications |
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