Please use this identifier to cite or link to this item:
|Title:||A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain||Authors:||Lee, A.T.-H.
Jitendrakumar, Shah J.
sodium hydrogen sulfide
|Issue Date:||2008||Citation:||Lee, A.T.-H., Jitendrakumar, Shah J., Khanna, S., Li, L., Cheng, Y., Moore, P.K. (2008). A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. Neuroscience 152 (1) : 89-96. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroscience.2007.11.052||Abstract:||The present study investigated the hypothesis that hydrogen sulfide (H2S) is pro-nociceptive in the formalin model of persistent inflammatory pain in the adult rat. Hind paw injection of formalin evoked a concentration-dependent increase in the hind paw concentration of H2S. Increased concentration of H2S was found in homogenates prepared from hind paws injected with 5% (but not 1.25%) formalin. Correspondingly, animal nociceptive flinching and hind paw edema were maximal with 5% formalin. Both nociceptive flinching and hind paw edema induced by injection of 5% formalin were attenuated by pretreatment with dl-propargylglycine (PPG; 50 mg/kg, i.p.) which is an inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). The effect of pretreatment with PPG was selective and the drug did not influence animal behavior or hind-paw edema with injection of 1.25% formalin. Furthermore, PPG pretreatment attenuated the induction of c-Fos in spinal laminae I-II following injection of 5% formalin. In contrast, co-injection of 1.25% formalin with sodium hydrogen sulfide (NaHS; 1 nmol/0.1 ml), a H2S donor, into the hind paw increased animal nociceptive behavior. Collectively, these findings show that the effect of peripheral H2S in the pathogenesis of inflammatory pain depends, at least in part, on the nociceptive intensity level. © 2008 IBRO.||Source Title:||Neuroscience||URI:||http://scholarbank.nus.edu.sg/handle/10635/25082||ISSN:||03064522||DOI:||10.1016/j.neuroscience.2007.11.052|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 24, 2020
WEB OF SCIENCETM
checked on Jan 17, 2020
checked on Dec 31, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.