Please use this identifier to cite or link to this item:
Title: Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells
Keywords: Flavonoids, anti-cancer properties, Nasopharyngeal carcinoma
Issue Date: 27-Dec-2010
Citation: ONG CHYE SUN (2010-12-27). Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells. ScholarBank@NUS Repository.
Abstract: In this study, we aim to determine the molecular mechanisms underlying the anti-tumour property of two flavonoids namely luteolin and quercetin on nasopharyngeal carcinoma (NPC) using two NPC cell lines, HK1 and CNE2. We first identified the mechanisms leading to quercetin-mediated cell cycle arrest in NPC cells. Quercetin was able to inhibit E2F-1 transcriptional activity, thus preventing the expression of cyclin E. In addition, quercetin induced apoptosis by up-regulating the expression of Bad and Bax in HK1 and CNE2 cells. In the second part of our study, luteolin was found to inhibit cell cycle progression at G1 phase via enhanced protein phosphorylation and proteasomal degradation of cyclin D1, which is mediated by suppression of the Akt-glycogen synthase kinase-3beta (GSK-3?)-cyclin D1 signaling pathway. In the last third part of this study we examined the sensitisation effect of quercetin and luteolin, both used at sub-cytotoxic concentrations on apoptosis induced by vincristine, a commonly used cancer therapeutic agents, in both CNE2 and HK1 cells. Taken together, data from this part of our study thus provide experimental evidence for potential application of combination therapy using these two flavonoids.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Ong CS.pdf4.74 MBAdobe PDF



Page view(s)

checked on Apr 12, 2019


checked on Apr 12, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.