Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbabio.2008.12.009
DC FieldValue
dc.titlemitoEnergetics and cancer cell fate
dc.contributor.authorChen, Z.X.
dc.contributor.authorVelaithan, R.
dc.contributor.authorPervaiz, S.
dc.date.accessioned2011-07-27T06:39:59Z
dc.date.available2011-07-27T06:39:59Z
dc.date.issued2009
dc.identifier.citationChen, Z.X., Velaithan, R., Pervaiz, S. (2009). mitoEnergetics and cancer cell fate. Biochimica et Biophysica Acta - Bioenergetics 1787 (5) : 462-467. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbabio.2008.12.009
dc.identifier.issn00052728
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25021
dc.description.abstractThe critical role of mitochondria in cell fate decisions has been well documented over the years. These observations have highlighted the way mitochondrial physiology controls cell survival and growth in the normal settings, the critical role of mitochondrial outer membrane permeabilization and altered mitoenergetics in cell death execution, and most importantly the association of altered mitochondrial metabolism with pathological states, in particular cancer. Reprogramming of cell metabolism, an invariable finding in cancer cells, is tightly linked to mitoenergetics as is evidenced by up-regulation of nutrient uptake and a pro-oxidant tilt in the intracellular milieu. The latter has also been demonstrated in oncogene-induced carcinogenesis models, notably as a functional outcome of Bcl-2 overexpression. Interestingly, even in that model, mitochondria appear to be the target as well. Thus the association of metabolic re-circuiting and altered mitoenergetics with the process of transformation has resulted in a paradigm shift in the way cancer development and progression is viewed today, which has tremendous implications for the development of novel and strategic therapeutic modalities. © 2009 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbabio.2008.12.009
dc.sourceScopus
dc.subjectBcl-2
dc.subjectCytochrome c oxidase
dc.subjectMitochondrial respiration
dc.subjectOxidative phosphorylation
dc.subjectROS
dc.subjectSuperoxide
dc.typeReview
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.bbabio.2008.12.009
dc.description.sourcetitleBiochimica et Biophysica Acta - Bioenergetics
dc.description.volume1787
dc.description.issue5
dc.description.page462-467
dc.identifier.isiut000266475400021
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