Please use this identifier to cite or link to this item:
|Title:||Adaptive evolution of tetrodotoxin resistance in animals||Authors:||Soong, T.W.
|Issue Date:||2006||Citation:||Soong, T.W., Venkatesh, B. (2006). Adaptive evolution of tetrodotoxin resistance in animals. Trends in Genetics 22 (11) : 621-626. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tig.2006.08.010||Abstract:||Tetrodotoxin (TTX), first isolated from pufferfish (tetraodontids), is a highly potent neurotoxin that selectively binds to voltage-gated sodium channels (Nav) in muscle and nerve tissues causing paralysis and death. Saxitoxin (STX) is a TTX-related neurotoxin produced by dinoflagellates. Recent investigations have implicated diverse substitutions in the P-loop regions of skeletal muscle and neuronal Nav channels in the convergent evolution of neurotoxin resistance in pufferfish, garter snakes and softshell clams, which has enabled them to feed on TTX- and STX-bearing organisms. © 2006 Elsevier Ltd. All rights reserved.||Source Title:||Trends in Genetics||URI:||http://scholarbank.nus.edu.sg/handle/10635/25004||ISSN:||01689525||DOI:||10.1016/j.tig.2006.08.010|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 26, 2020
WEB OF SCIENCETM
checked on Sep 18, 2020
checked on Sep 22, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.