Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbamem.2006.12.010
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dc.titleAtomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria
dc.contributor.authorLi, A.
dc.contributor.authorLee, P.Y.
dc.contributor.authorLim, C.T.
dc.contributor.authorHo, B.
dc.contributor.authorDing, J.L.
dc.date.accessioned2011-07-26T07:05:45Z
dc.date.available2011-07-26T07:05:45Z
dc.date.issued2007
dc.identifier.citationLi, A., Lee, P.Y., Lim, C.T., Ho, B., Ding, J.L. (2007). Atomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria. Biochimica et Biophysica Acta - Biomembranes 1768 (3) : 411-418. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbamem.2006.12.010
dc.identifier.issn00052736
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24873
dc.description.abstractThe antibacterial effect of the endotoxin-binding Sushi peptides against Gram-negative bacteria (GNB) is investigated in this study. Similar characteristics observed for Atomic force microscopy (AFM) images of peptide-treated Escherichia coli and Pseudomonas aeruginosa suggest that the Sushi peptides (S3) evoke comparable mechanism of action against different strains of GNB. The results also indicate that the Sushi peptides appear to act in three stages: damage of the bacterial outer membrane, permeabilization of the inner membrane and disintegration of both membranes. The AFM approach has provided vivid and detailed close-up images of the GNB undergoing various stages of antimicrobial peptide actions at the nanometer scale. The AFM results support our hypothesis that the S3 peptide perturbs the GNB membrane via the "carpet-model" and thus, provide important insights into their antimicrobial mechanisms. © 2006 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbamem.2006.12.010
dc.sourceScopus
dc.subjectAntimicrobial Sushi peptide
dc.subjectAtomic force microscopy
dc.subjectGram negative bacteria
dc.subjectLipopolysaccharide
dc.subjectMembranolytic
dc.typeArticle
dc.contributor.departmentINDUSTRIAL & SYSTEMS ENGINEERING
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentMICROBIOLOGY
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.bbamem.2006.12.010
dc.description.sourcetitleBiochimica et Biophysica Acta - Biomembranes
dc.description.volume1768
dc.description.issue3
dc.description.page411-418
dc.identifier.isiut000245060200004
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