PARTICLE ENGINEERING OF AMORPHOUS SOLID DISPERSIONS USING CONTINUOUS ANTISOLVENT EXTRACTION IN PICKERING EMULSIONS

Abstract

In order to produce effective composite co-process excipients-drug particles, this thesis explores the field of particle engineering by continuously extracting Pickering emulsions' anti-solvent. Through co-processing, silica nanoparticles improve particle flowability, facilitate one-pot emulsification, and stabilize the emulsion. The study entails creating composite particles with different indomethacin drug loadings using fumed silica and hydroxypropylmethylcellulose acetate succinate (HPMCAS). In Chapter 3, emulsion production and extraction parameters are examined, and the effects of variables such as the weight fraction of silica nanoparticles on particle characteristics are examined. Initial tableting investigations lay the groundwork for additional research. In Chapter 4, the benefits of continuous processing are emphasized. A lab-scale system that effectively generates particles for tableting trials is described, along with ways to reduce spatial footprint and improve scalability. Building on Chapters 3 and 4, Chapter 5 introduces indomethacin into particles that serve as co-excipients.