Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/24589
Title: Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination
Authors: Soh, S.E. 
Ong, D.Q.R.
Gerez, I.
Shek, L.P.-C. 
Lee, B.W. 
Aw, M. 
Zhang, X.
Chollate, P.
Keywords: Hepatitis B
Probiotics
Vaccination
Issue Date: 2010
Citation: Soh, S.E., Ong, D.Q.R., Gerez, I., Shek, L.P.-C., Lee, B.W., Aw, M., Zhang, X., Chollate, P. (2010). Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination. Vaccine 28 (14) : 2577-2579. ScholarBank@NUS Repository.
Abstract: Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n = 28): 187.97 (180.70-195.24), probiotic (n = 29): 345.70 (339.41-351.99) mIU/ml] (p = 0.069), but not those who received 3 monovalent doses [placebo (n = 68): 302.34 (296.31-308.37), probiotic (n = 77): 302.06 (296.31-307.81) mIU/ml] (p = 0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules. © 2010 Elsevier Ltd. All rights reserved.
Source Title: Vaccine
URI: http://scholarbank.nus.edu.sg/handle/10635/24589
ISSN: 0264410X
Appears in Collections:Staff Publications

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