Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ophtha.2009.07.044
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dc.titleAre Myopic Eyes Less Likely to Have Diabetic Retinopathy?
dc.contributor.authorLim, L.S.
dc.contributor.authorLamoureux, E.
dc.contributor.authorTay, W.T.
dc.contributor.authorWong, T.Y.
dc.contributor.authorSaw, S.M.
dc.contributor.authorMitchell, P.
dc.date.accessioned2011-07-26T03:01:17Z
dc.date.available2011-07-26T03:01:17Z
dc.date.issued2010
dc.identifier.citationLim, L.S., Lamoureux, E., Tay, W.T., Wong, T.Y., Saw, S.M., Mitchell, P. (2010). Are Myopic Eyes Less Likely to Have Diabetic Retinopathy?. Ophthalmology 117 (3) : 524-530. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ophtha.2009.07.044
dc.identifier.issn01616420
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24588
dc.description.abstractPurpose: Eyes with myopia may be less likely to develop diabetic retinopathy (DR). The relationship between refractive error, ocular biometry, and DR therefore was investigated. Design: Population-based, cross-sectional study. Participants: Persons with diabetes from the Singapore Malay Eye Study (SiMES). Methods: Diabetes mellitus was defined as random glucose of 11.1 mmol/l or more, use of diabetic medication, or a physician diagnosis of diabetes. Spherical equivalent refraction (SE) was assessed using an autokeratorefractometer and subjective refraction. Axial length (AL) and anterior chamber depth (ACD) were measured by IOLMaster (Carl Zeiss Meditec AG, Jena, Germany). Diabetic retinopathy was graded from retinal photographs. Main Outcome Measures: Any DR was defined by characteristic lesions defined by the Early Treatment Diabetic Retinopathy Study (ETDRS); moderate DR by ETDRS retinopathy severity scores of 43 or higher; and vision-threatening retinopathy by severe nonproliferative retinopathy, proliferative DR, or clinically significant macular edema. Results: Of 3280 adult Malay participants (78.7% response), 629 persons with diabetes contributed to this analysis. In multivariate analyses adjusting for age, gender, education, height, cataract, hypertension, hemoglobin A1c, and other factors, eyes with myopic SE were less likely to have any DR (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96; P = 0.002, per 1-diopter [D] decrease), moderate DR (OR, 0.83; 95% CI, 0.73-0.93; P = 0.001, per 1-D decrease), and vision-threatening DR (OR, 0.77; 95% CI, 0.67-0.88; P<0.001, per 1-D decrease). Eyes with longer AL were less likely to have any DR (OR, 0.86; 95% CI, 0.75-0.99; P = 0.041, per 1-mm increase), moderate DR (OR, 0.80; 95% CI, 0.62-1.05; P = 0.11, per 1-mm increase), and vision-threatening DR (OR, 0.63; 95% CI, 0.40-0.99; P = 0.044, per mm increase). Eyes with deeper ACD were less likely to have moderate DR (OR, 0.32; 95% CI, 0.16-0.64; P = 0.001, per 1-mm increase) and vision-threatening DR (OR, 0.14; 95% CI, 0.06-0.36; P = 0.001, per 1-mm increase). Conclusions: Myopic refraction and longer AL are associated with a lower risk of DR, particularly vision-threatening retinopathy, without any evidence of a threshold. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2010 American Academy of Ophthalmology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ophtha.2009.07.044
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1016/j.ophtha.2009.07.044
dc.description.sourcetitleOphthalmology
dc.description.volume117
dc.description.issue3
dc.description.page524-530
dc.identifier.isiut000275101000017
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