Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.breast.2009.03.008
DC FieldValue
dc.titleXRCC1 gene polymorphisms and breast cancer risk in different populations: A meta-analysis
dc.contributor.authorLi, H.
dc.contributor.authorHa, T.C.
dc.contributor.authorTai, B.C.
dc.date.accessioned2011-07-26T03:01:16Z
dc.date.available2011-07-26T03:01:16Z
dc.date.issued2009
dc.identifier.citationLi, H., Ha, T.C., Tai, B.C. (2009). XRCC1 gene polymorphisms and breast cancer risk in different populations: A meta-analysis. Breast 18 (3) : 183-191. ScholarBank@NUS Repository. https://doi.org/10.1016/j.breast.2009.03.008
dc.identifier.issn09609776
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24587
dc.description.abstractWe performed a meta-analysis to investigate the role of XRCC1 polymorphisms Arg194Trp, Arg280His and Arg399Gln in breast cancer. The results were pooled in a manner that appropriately reflects a biological model of gene effect using a random effects logistic regression model without multiple comparisons. Forty studies from 31 reports were included with 10 465 cases and 10 888 controls at Arg194Trp, 6156 cases and 5806 controls at Arg280His, and 21 467 cases and 22 766 controls at Arg399Gln. Our analysis found a tendency towards a recessive effect of Arg280His variant in Asian population only (His/His vs. Arg/Arg + Arg/His: OR = 2.27, 95% CI = 0.82, 6.31). An increased breast cancer risk with a recessive effect was also suggested for Arg399Gln variant in Asian population (Gln/Gln vs. Arg/Arg + Arg/Gln: OR = 1.59, 95% CI = 1.22, 2.09) only. These findings suggest that polymorphisms Arg280His and Arg399Gln may modify breast cancer risk differently in Caucasian and Asian populations. © 2009 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.breast.2009.03.008
dc.sourceScopus
dc.subjectArg194Trp
dc.subjectArg280His
dc.subjectArg399Gln
dc.subjectBreast cancer
dc.subjectXRCC1 gene polymorphisms
dc.typeArticle
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.breast.2009.03.008
dc.description.sourcetitleBreast
dc.description.volume18
dc.description.issue3
dc.description.page183-191
dc.identifier.isiut000267961000008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

53
checked on May 16, 2022

WEB OF SCIENCETM
Citations

52
checked on May 16, 2022

Page view(s)

283
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.