Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.taap.2007.05.013
DC FieldValue
dc.titleReduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity?
dc.contributor.authorTavintharan, S.
dc.contributor.authorLim, S.C.
dc.contributor.authorOng, C.N.
dc.contributor.authorJeyaseelan, K.
dc.contributor.authorSivakumar, M.
dc.contributor.authorSum, C.F.
dc.date.accessioned2011-07-25T07:16:41Z
dc.date.available2011-07-25T07:16:41Z
dc.date.issued2007
dc.identifier.citationTavintharan, S., Lim, S.C., Ong, C.N., Jeyaseelan, K., Sivakumar, M., Sum, C.F. (2007). Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity?. Toxicology and Applied Pharmacology 223 (2) : 173-179. ScholarBank@NUS Repository. https://doi.org/10.1016/j.taap.2007.05.013
dc.identifier.issn0041008X
dc.identifier.issn10960333
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24481
dc.description.abstractLowering of low-density lipoprotein cholesterol is well achieved by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins). Statins inhibit the conversion of HMG-CoA to mevalonate, a precursor for cholesterol and coenzyme Q10 (CoQ10). In HepG2 cells, simvastatin decreased mitochondrial CoQ10 levels, and at higher concentrations was associated with a moderately higher degree of cell death, increased DNA oxidative damage and a reduction in ATP synthesis. Supplementation of CoQ10, reduced cell death and DNA oxidative stress, and increased ATP synthesis. It is suggested that CoQ10 deficiency plays an important role in statin-induced hepatopathy, and that CoQ10 supplementation protects HepG2 cells from this complication. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.taap.2007.05.013
dc.sourceScopus
dc.subjectHepatotoxicity
dc.subjectOxidative stress
dc.subjectStatins
dc.subjectTransaminitis
dc.subjectUbiquinone
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1016/j.taap.2007.05.013
dc.description.sourcetitleToxicology and Applied Pharmacology
dc.description.volume223
dc.description.issue2
dc.description.page173-179
dc.identifier.isiut000249513400011
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