Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.canlet.2008.01.006
DC Field | Value | |
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dc.title | Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma | |
dc.contributor.author | Liu, Z.-M. | |
dc.contributor.author | Li, L.-Q. | |
dc.contributor.author | Peng, M.-H. | |
dc.contributor.author | Liu, T.-W. | |
dc.contributor.author | Qin, Z. | |
dc.contributor.author | Guo, Y. | |
dc.contributor.author | Xiao, K.-Y. | |
dc.contributor.author | Ye, X.-P. | |
dc.contributor.author | Mo, X.-S. | |
dc.contributor.author | Qin, X. | |
dc.contributor.author | Li, S. | |
dc.contributor.author | Peng, T. | |
dc.contributor.author | Yan, L.-N. | |
dc.contributor.author | Shen, H.-M. | |
dc.contributor.author | Ong, C.N. | |
dc.contributor.author | Wang, L. | |
dc.contributor.author | Wang, Q. | |
dc.contributor.author | Santella, R.M. | |
dc.contributor.author | Peng, T. | |
dc.contributor.author | Wang, K.-b. | |
dc.contributor.author | Liang, R.-x. | |
dc.contributor.author | Wei, Z.-l. | |
dc.date.accessioned | 2011-07-25T06:58:35Z | |
dc.date.available | 2011-07-25T06:58:35Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Liu, Z.-M., Li, L.-Q., Peng, M.-H., Liu, T.-W., Qin, Z., Guo, Y., Xiao, K.-Y., Ye, X.-P., Mo, X.-S., Qin, X., Li, S., Peng, T., Yan, L.-N., Shen, H.-M., Ong, C.N., Wang, L., Wang, Q., Santella, R.M., Peng, T., Wang, K.-b., Liang, R.-x., Wei, Z.-l. (2008). Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Letters 263 (2) : 212-222. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.01.006 | |
dc.identifier.issn | 03043835 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/24439 | |
dc.description.abstract | Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p < 0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p = 0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region. © 2008 Elsevier Ireland Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2008.01.006 | |
dc.source | Scopus | |
dc.subject | Aflatoxin | |
dc.subject | HBV | |
dc.subject | Hepatocellular carcinoma | |
dc.subject | Oxidative stress | |
dc.type | Article | |
dc.contributor.department | COMMUNITY,OCCUPATIONAL & FAMILY MEDICINE | |
dc.description.doi | 10.1016/j.canlet.2008.01.006 | |
dc.description.sourcetitle | Cancer Letters | |
dc.description.volume | 263 | |
dc.description.issue | 2 | |
dc.description.page | 212-222 | |
dc.identifier.isiut | 000255810500008 | |
Appears in Collections: | Staff Publications |
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