Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.01.006
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dc.titleHepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma
dc.contributor.authorLiu, Z.-M.
dc.contributor.authorLi, L.-Q.
dc.contributor.authorPeng, M.-H.
dc.contributor.authorLiu, T.-W.
dc.contributor.authorQin, Z.
dc.contributor.authorGuo, Y.
dc.contributor.authorXiao, K.-Y.
dc.contributor.authorYe, X.-P.
dc.contributor.authorMo, X.-S.
dc.contributor.authorQin, X.
dc.contributor.authorLi, S.
dc.contributor.authorPeng, T.
dc.contributor.authorYan, L.-N.
dc.contributor.authorShen, H.-M.
dc.contributor.authorOng, C.N.
dc.contributor.authorWang, L.
dc.contributor.authorWang, Q.
dc.contributor.authorSantella, R.M.
dc.contributor.authorPeng, T.
dc.contributor.authorWang, K.-b.
dc.contributor.authorLiang, R.-x.
dc.contributor.authorWei, Z.-l.
dc.date.accessioned2011-07-25T06:58:35Z
dc.date.available2011-07-25T06:58:35Z
dc.date.issued2008
dc.identifier.citationLiu, Z.-M., Li, L.-Q., Peng, M.-H., Liu, T.-W., Qin, Z., Guo, Y., Xiao, K.-Y., Ye, X.-P., Mo, X.-S., Qin, X., Li, S., Peng, T., Yan, L.-N., Shen, H.-M., Ong, C.N., Wang, L., Wang, Q., Santella, R.M., Peng, T., Wang, K.-b., Liang, R.-x., Wei, Z.-l. (2008). Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Letters 263 (2) : 212-222. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.01.006
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24439
dc.description.abstractBiomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p < 0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p = 0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2008.01.006
dc.sourceScopus
dc.subjectAflatoxin
dc.subjectHBV
dc.subjectHepatocellular carcinoma
dc.subjectOxidative stress
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1016/j.canlet.2008.01.006
dc.description.sourcetitleCancer Letters
dc.description.volume263
dc.description.issue2
dc.description.page212-222
dc.identifier.isiut000255810500008
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