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https://doi.org/10.1016/j.canlet.2008.01.006
Title: | Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma | Authors: | Liu, Z.-M. Li, L.-Q. Peng, M.-H. Liu, T.-W. Qin, Z. Guo, Y. Xiao, K.-Y. Ye, X.-P. Mo, X.-S. Qin, X. Li, S. Peng, T. Yan, L.-N. Shen, H.-M. Ong, C.N. Wang, L. Wang, Q. Santella, R.M. Peng, T. Wang, K.-b. Liang, R.-x. Wei, Z.-l. |
Keywords: | Aflatoxin HBV Hepatocellular carcinoma Oxidative stress |
Issue Date: | 2008 | Citation: | Liu, Z.-M., Li, L.-Q., Peng, M.-H., Liu, T.-W., Qin, Z., Guo, Y., Xiao, K.-Y., Ye, X.-P., Mo, X.-S., Qin, X., Li, S., Peng, T., Yan, L.-N., Shen, H.-M., Ong, C.N., Wang, L., Wang, Q., Santella, R.M., Peng, T., Wang, K.-b., Liang, R.-x., Wei, Z.-l. (2008). Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Letters 263 (2) : 212-222. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.01.006 | Abstract: | Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p < 0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p = 0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region. © 2008 Elsevier Ireland Ltd. All rights reserved. | Source Title: | Cancer Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/24439 | ISSN: | 03043835 | DOI: | 10.1016/j.canlet.2008.01.006 |
Appears in Collections: | Staff Publications |
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