Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.bcp.2006.04.019
DC Field | Value | |
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dc.title | Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells | |
dc.contributor.author | Zhou, J. | |
dc.contributor.author | Zhang, S. | |
dc.contributor.author | Choon-Nam, O. | |
dc.contributor.author | Shen, H.-M. | |
dc.date.accessioned | 2011-07-25T06:58:34Z | |
dc.date.available | 2011-07-25T06:58:34Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Zhou, J., Zhang, S., Choon-Nam, O., Shen, H.-M. (2006). Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochemical Pharmacology 72 (2) : 132-144. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bcp.2006.04.019 | |
dc.identifier.issn | 00062952 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/24438 | |
dc.description.abstract | Andrographolide (Andro), a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, is known to possess potent anti-inflammatory activity. In this study, Andro induced apoptosis in human cancer cells via activation of caspase 8 in the extrinsic death receptor pathway and subsequently with the participation of mitochondria. Andro triggered a caspase 8-dependent Bid cleavage, followed by a series of sequential events including Bax conformational change and mitochondrial translocation, cytochrome c release from mitochondria, and activation of caspase 9 and 3. Inhibition of caspase 8 blocked Bid cleavage and Bax conformational change. Consistently, knockdown of Bid protein using small interfering RNA (siRNA) technique suppressed Andro-induced Bax conformational change and apoptosis. In conclusion, the pro-apoptotic Bcl-2 family members (Bid and Bax) are the key mediators in relaying the cell death signaling initiated by Andro from caspase 8 to mitochondria and then to downstream effector caspases, and eventually leading to apoptotic cell death. © 2006 Elsevier Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bcp.2006.04.019 | |
dc.source | Scopus | |
dc.subject | Andrographolide | |
dc.subject | Apoptosis | |
dc.subject | Bax | |
dc.subject | Bcl-2 family | |
dc.subject | Bid | |
dc.subject | Mitochondria | |
dc.type | Article | |
dc.contributor.department | COMMUNITY,OCCUPATIONAL & FAMILY MEDICINE | |
dc.description.doi | 10.1016/j.bcp.2006.04.019 | |
dc.description.sourcetitle | Biochemical Pharmacology | |
dc.description.volume | 72 | |
dc.description.issue | 2 | |
dc.description.page | 132-144 | |
dc.identifier.isiut | 000238700300002 | |
Appears in Collections: | Staff Publications |
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