Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.canlet.2005.04.013
| Title: | Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer | Authors: | Du, H. Bay, B.-H. Mahendran, R. Olivo, M. |
Keywords: | CNE-2 Cytokines Hypericin IL-6 Interleukin-6 Nasopharyngeal cancer NPC PDT Photodynamic therapy |
Issue Date: | 2006 | Citation: | Du, H., Bay, B.-H., Mahendran, R., Olivo, M. (2006). Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer. Cancer Letters 235 (2) : 202-208. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.04.013 | Abstract: | Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upregulated in PDT-treated CNE-2 poorly differentiated cells but not in HK1 well differentiated cells. In vivo, IL-6 mRNA expression was elevated in PDT-treated CNE-2 tumors but not in HK1 tumors. In conclusion, the study elucidated that the cell type, degree of histological differentiation and the basal expression of the cytokine influence the cytokine response following PDT. © 2005 Elsevier Ireland Ltd. All rights reserved. | Source Title: | Cancer Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/24204 | ISSN: | 03043835 | DOI: | 10.1016/j.canlet.2005.04.013 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
25
checked on Sep 19, 2020
WEB OF SCIENCETM
Citations
22
checked on Sep 11, 2020
Page view(s)
270
checked on Sep 22, 2020
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.