Please use this identifier to cite or link to this item: https://doi.org/10.20892/j.issn.2095-3941.2018.0288
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dc.title(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy
dc.contributor.authorTan, Janice SH
dc.contributor.authorGoh, Charles XY
dc.contributor.authorKohl, Yen Sin
dc.contributor.authorLi, Youquan
dc.contributor.authorTuan, Jeffrey KL
dc.contributor.authorChua, Eu Tiong
dc.contributor.authorTan, Terence WK
dc.contributor.authorWang, Michael LC
dc.contributor.authorLee, Lui Shiong
dc.contributor.authorTay, Kae Jack
dc.contributor.authorKanesvaran, Ravindran
dc.contributor.authorToh, Chee Keong
dc.contributor.authorTong, Aaron KT
dc.contributor.authorLam, Winnie WC
dc.contributor.authorChua, Melvin LK
dc.date.accessioned2023-06-08T10:27:51Z
dc.date.available2023-06-08T10:27:51Z
dc.date.issued2019-02-01
dc.identifier.citationTan, Janice SH, Goh, Charles XY, Kohl, Yen Sin, Li, Youquan, Tuan, Jeffrey KL, Chua, Eu Tiong, Tan, Terence WK, Wang, Michael LC, Lee, Lui Shiong, Tay, Kae Jack, Kanesvaran, Ravindran, Toh, Chee Keong, Tong, Aaron KT, Lam, Winnie WC, Chua, Melvin LK (2019-02-01). (68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy. CANCER BIOLOGY & MEDICINE 16 (1) : 157-+. ScholarBank@NUS Repository. https://doi.org/10.20892/j.issn.2095-3941.2018.0288
dc.identifier.issn2095-3941
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/241760
dc.description.abstractObjective: Prostate cancers (PCa) in Asian individuals are molecularly distinct from those found in their Caucasian counterparts. There is no risk stratification tool for Asian men with rapid biochemical recurrence (BCR) following radical prostatectomy (RadP). This study aims to assess the detection rate of 68Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography (PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-RadP. Methods: 68Ga PSMA-PET and CT body with/without bone scan [conventional workup (CWU)] were performed in 55 Asian patients with BCR within 36 months post-RadP. Two blinded reviewers assessed the images. Detection rates of 68Ga PSMAPET/ CT were evaluated, and impact on management was reviewed by comparison with CWU. Results: Median time to BCR post-RadP was 8.1 months. Detection rate for 68Ga PSMA-PET/CT was 80% (44/55). A positive scan was significantly associated with increasing prostate-specific antigen (PSA) level [odds ratio (OR) = 1.13 (95% CI 1.05-1.30), P = 0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, 68Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44 (56.8%) patients: 10 to hormonal therapy (HT) and whole pelvis radiotherapy (RT) in addition to bed RT, and 15 to palliative HT alone. Conclusions: In the present report, we demonstrated the diagnostic and treatment decision utility of 68Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels (< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease.
dc.language.isoen
dc.publisherCHINESE ANTI-CANCER ASSOC
dc.sourceElements
dc.subject68Ga PSMA PET/CT
dc.subjectprostate cancer
dc.subjectAsian
dc.subjectdiagnostic
dc.subjectrecurrence
dc.subjectprostatectomy
dc.subjectsalvage radiotherapy
dc.typeArticle
dc.date.updated2023-06-05T23:58:53Z
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.20892/j.issn.2095-3941.2018.0288
dc.description.sourcetitleCANCER BIOLOGY & MEDICINE
dc.description.volume16
dc.description.issue1
dc.description.page157-+
dc.published.statePublished
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