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https://doi.org/10.3390/antibiotics11010047
Title: | The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age | Authors: | Guo, Huiling Hildon, Zoe Jane-Lara Lye, David Chien Boon Straughan, Paulin Tay Chow, Angela |
Keywords: | antimicrobial resistance public knowledge inappropriate antibiotic use population-based survey effect modification |
Issue Date: | 30-Dec-2021 | Publisher: | MDPI | Citation: | Guo, Huiling, Hildon, Zoe Jane-Lara, Lye, David Chien Boon, Straughan, Paulin Tay, Chow, Angela (2021-12-30). The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age. ANTIBIOTICS-BASEL 11 (1). ScholarBank@NUS Repository. https://doi.org/10.3390/antibiotics11010047 | Abstract: | Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and January 2021. Knowledge of antibiotic use and AMR using the World Health Organization’s Multi-Country AMR Survey questionnaire, and antibiotic practices were examined. Multivariable logistic regression was performed to identify factors associated with inappropriate antibiotic use and examine effect measure modifications. Results: After adjusting for potential con-founding, poor knowledge of antibiotic use was associated with a 3x increased odds of inappropriate antibiotic use in adults aged ≥50 years (aOR 3.11, 95% CI [2.24–4.32]), 5× increased odds in those aged 35–49 years (aOR 4.88, 95% CI [3.32–7.16]), and 7× increased odds in those aged 21–34 years (aOR 6.58, 95% CI [4.19–10.33]). While there was no statistically significant association in adults aged ≥50 years, poor knowledge of AMR increased the odds of inappropriate antibiotic use by 4 times in adults aged 35–49 years (aOR 3.73, 95% CI [1.53–9.11]) and 5 times in those aged 21–34 years (aOR 4.90, 95% CI [1.84–13.02]). Conclusions: Targeted educational interventions for specific age groups are needed in conjunction with empowering the public with knowledge of antibiotic use and AMR. | Source Title: | ANTIBIOTICS-BASEL | URI: | https://scholarbank.nus.edu.sg/handle/10635/241418 | ISSN: | 2079-6382 | DOI: | 10.3390/antibiotics11010047 |
Appears in Collections: | Staff Publications Elements Students Publications |
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