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|Title:||Early event-related potentials changes during simple mental calculation in Chinese older adults with mild cognitive impairment: A case-control study||Authors:||Li, X.
Event-related potentials (ERP)
Mild cognitive impairment
|Issue Date:||2010||Citation:||Li, X., Zhang, Y., Meng, Q., Feng, L. (2010). Early event-related potentials changes during simple mental calculation in Chinese older adults with mild cognitive impairment: A case-control study. Neuroscience Letters 475 (1) : 29-32. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2010.03.038||Abstract:||The aim was to examine early event-related potential (ERP) changes during mental arithmetic calculation task in mild cognitive impairment patients compared to healthy elderly. 16 mild cognitive impairment (MCI) subjects and 16 healthy Chinese older adults were studied. Event-related potentials were elicited using a simple mental calculation task. Performance on arithmetic calculation task, and the latency and amplitude of early event-related potential components (N1, P1, N170, and P2) were compared between the two groups. The reaction time of MCI group was significantly longer than that of control group (1691.03 ± 94.59 vs 1539.55 ± 27.76, P<0.01). The correct rate of MCI group (0.9463 ± 0.04) was significantly lower than that of control group (0.9776 ± 0.02, P< 0.01). The latency of temporal-occipital N170 and central-prefrontal P2 of MCI group were significantly prolonged compared to controls. MCI subjects presented significantly higher P2 amplitude. Compared with healthy controls, N170 was significantly lower at left temporal-occipital region and higher at right temporal-occipital region in mild cognitive impairment. Mild cognitive impairment patients had deficit on simple calculation. The early arithmetic calculation processing mechanism of mild cognitive impairment patients may be different from normal people. © 2010 Elsevier Ireland Ltd.||Source Title:||Neuroscience Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/24100||ISSN:||03043940||DOI:||10.1016/j.neulet.2010.03.038|
|Appears in Collections:||Staff Publications|
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