Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2005.07.002
DC FieldValue
dc.titleCombination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity
dc.contributor.authorPook, S.-H.
dc.contributor.authorMahendran, R.
dc.contributor.authorToh, C.-K.
dc.date.accessioned2011-07-18T10:10:51Z
dc.date.available2011-07-18T10:10:51Z
dc.date.issued2006
dc.identifier.citationPook, S.-H., Mahendran, R., Toh, C.-K. (2006). Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity. Cancer Letters 238 (1) : 146-152. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.07.002
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24056
dc.description.abstractThe cytotoxic activity of Brostallicin was previously shown to be enhanced in the presence of high glutathione and glutathione transferase levels. We hypothesized that thiol antioxidants, N-acetylcysteine and Silibinin, could potentiate Brostallicin's cytotoxicity in a similar way. HepG2 and CNE-2 cells were treated with N-acetylcysteine, Silibinin and Brostallicin, either alone or in combination. Surprisingly, we found that NAC and Silibinin had adverse effects on Brostallicin's cytotoxicity. The mechanism underlying the interaction involved the apoptotic pathway as we demonstrated an increase in Bcl-2 protein levels and decrease in caspase 3 activity with the Silibinin-Brostallicin combination. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2005.07.002
dc.sourceScopus
dc.subjectAntioxidants
dc.subjectApoptosis
dc.subjectBcl-2 proteins
dc.subjectCaspases
dc.subjectChemotherapy
dc.typeArticle
dc.contributor.departmentSURGERY
dc.description.doi10.1016/j.canlet.2005.07.002
dc.description.sourcetitleCancer Letters
dc.description.volume238
dc.description.issue1
dc.description.page146-152
dc.identifier.isiut000238931400017
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Oct 17, 2019

WEB OF SCIENCETM
Citations

9
checked on Oct 10, 2019

Page view(s)

320
checked on Oct 14, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.