Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1745-7254.2007.00625.x
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dc.titleFrom blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain
dc.contributor.authorKaur, Charanjit
dc.contributor.authorDheen, S Thameem
dc.contributor.authorLing, Eng-ang
dc.date.accessioned2011-07-18T08:45:44Z
dc.date.available2011-07-18T08:45:44Z
dc.date.issued2007-08-01
dc.identifier.citationKaur, Charanjit, Dheen, S Thameem, Ling, Eng-ang (2007-08-01). From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain. Acta Pharmacologica Sinica 28 (8) : 1087-1096. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1745-7254.2007.00625.x
dc.identifier.issn1671-4083
dc.identifier.issn1745-7254
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/163911
dc.description.abstractAmoeboid microglial cells (AMC) in the developing brain are active macrophages. The macrophagic nature of these cells has been demonstrated by many methods, such as the localization of various hydrolytic enzymes and the presence of complement type 3 surface receptors in them. More importantly is the direct visualization of these cells engaged in the phagocytosis of degenerating cells at the ultrastructural level. Further evidence of them being active macrophages is the avid internalization of tracers administered by the intravenous or intraperitoneal routes in developing rats. The potential involvement of AMC in immune functions is supported by the induced expression of major histocompatibility complex class I and II antigens on them when challenged by lipopolysaccharide or interferon-?. Im-munosuppressive drugs, such as glucocorticoids and immune function-enhancing drugs like melatonin, affect the expression of surface receptors and antigens and the release of cytokines by AMC. Recent studies in our laboratory have shown the expression of insulin-like growth factors, endothelins, 2?,3?-cyclic nucleotide 3?-phosphodiesterase, and N-methyl-D-asparate receptors. This along with the release of chemokines, such as stromal derived factor-1a and monocyte chemoattractant protein-1, suggests multiple functional roles of AMC in early brain development. © 2007 CPS and SIMM.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1745-7254.2007.00625.x
dc.language.isoen
dc.publisherSpringer Nature
dc.sourceScopus
dc.subjectAmoeboid microglial cells
dc.subjectDeveloping brain
dc.subjectFunctions
dc.typeReview
dc.date.updated2020-01-17T07:44:47Z
dc.contributor.departmentDEPT OF ANATOMY
dc.description.doi10.1111/j.1745-7254.2007.00625.x
dc.description.sourcetitleActa Pharmacologica Sinica
dc.description.volume28
dc.description.issue8
dc.description.page1087-1096
dc.description.codenCYLPD
dc.identifier.isiut000248512000001
dc.description.placeChina
dc.published.statePublished
dc.grant.idR181-000-065-112
dc.grant.idR181-000-098-112
dc.grant.fundingagencyNational University of Singapore
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