Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1470-2045(22)00505-8
Title: International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: lessons from the COVID-19 pandemic
Authors: Lee, VHF
Adham, M
Ben Kridis, W
Bossi, P
Chen, MY
Chitapanarux, I
Gregoire, V
Hao, SP
Ho, C
Ho, GF
Kannarunimit, D
Kwong, DLW
Lam, KO
Lam, WKJ
Le, QT
Lee, AWM
Lee, NY
Leung, TW
Licitra, L
Lim, DWT
Lin, JC
Loh, KS
Lou, PJ
Machiels, JP
Mai, HQ
Mesía, R
Ng, WT
Ngan, RKC
Tay, JK
Tsang, RKY 
Tong, CC
Wang, HM
Wee, JT
Keywords: Humans
COVID-19
Pandemics
Herpesvirus 4, Human
SARS-CoV-2
Nasopharyngeal Carcinoma
Epstein-Barr Virus Infections
DNA
Nasopharyngeal Neoplasms
Issue Date: 1-Dec-2022
Publisher: Elsevier BV
Citation: Lee, VHF, Adham, M, Ben Kridis, W, Bossi, P, Chen, MY, Chitapanarux, I, Gregoire, V, Hao, SP, Ho, C, Ho, GF, Kannarunimit, D, Kwong, DLW, Lam, KO, Lam, WKJ, Le, QT, Lee, AWM, Lee, NY, Leung, TW, Licitra, L, Lim, DWT, Lin, JC, Loh, KS, Lou, PJ, Machiels, JP, Mai, HQ, Mesía, R, Ng, WT, Ngan, RKC, Tay, JK, Tsang, RKY, Tong, CC, Wang, HM, Wee, JT (2022-12-01). International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: lessons from the COVID-19 pandemic. The Lancet Oncology 23 (12) : e544-e551. ScholarBank@NUS Repository. https://doi.org/10.1016/S1470-2045(22)00505-8
Abstract: The effects of the COVID-19 pandemic continue to constrain health-care staff and resources worldwide, despite the availability of effective vaccines. Aerosol-generating procedures such as endoscopy, a common investigation tool for nasopharyngeal carcinoma, are recognised as a likely cause of SARS-CoV-2 spread in hospitals. Plasma Epstein-Barr virus (EBV) DNA is considered the most accurate biomarker for the routine management of nasopharyngeal carcinoma. A consensus statement on whether plasma EBV DNA can minimise the need for or replace aerosol-generating procedures, imaging methods, and face-to-face consultations in managing nasopharyngeal carcinoma is urgently needed amid the current pandemic and potentially for future highly contagious airborne diseases or natural disasters. We completed a modified Delphi consensus process of three rounds with 33 international experts in otorhinolaryngology or head and neck surgery, radiation oncology, medical oncology, and clinical oncology with vast experience in managing nasopharyngeal carcinoma, representing 51 international professional societies and national clinical trial groups. These consensus recommendations aim to enhance consistency in clinical practice, reduce ambiguity in delivering care, and offer advice for clinicians worldwide who work in endemic and non-endemic regions of nasopharyngeal carcinoma, in the context of COVID-19 and other airborne pandemics, and in future unexpected settings of severe resource constraints and insufficiency of personal protective equipment.
Source Title: The Lancet Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/238341
ISSN: 1470-2045
1474-5488
DOI: 10.1016/S1470-2045(22)00505-8
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