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Title: Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation
Authors: Goh, Yonggeng
Balasundaram, Ghayathri
Tan, Hui Min 
Putti, Thomas Choudary 
Ng, Celene Wei Qi 
Fang, Eric
Bi, Renzhe
Tang, Siau Wei 
Buhari, Shaik Ahmad 
Hartman, Mikael 
Chan, Ching Wan 
Lim, Yi Ting 
Olivo, Malini 
Quek, Swee Tian 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
Issue Date: 1-Oct-2022
Publisher: MDPI
Citation: Goh, Yonggeng, Balasundaram, Ghayathri, Tan, Hui Min, Putti, Thomas Choudary, Ng, Celene Wei Qi, Fang, Eric, Bi, Renzhe, Tang, Siau Wei, Buhari, Shaik Ahmad, Hartman, Mikael, Chan, Ching Wan, Lim, Yi Ting, Olivo, Malini, Quek, Swee Tian (2022-10-01). Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation. DIAGNOSTICS 12 (10). ScholarBank@NUS Repository.
Abstract: A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal “mass-like” nodules seen within the inferior portion suggested malignant transformation of a lipomatous lesion called for cross sectional imaging, such as MRI or invasive biopsy or excision for histological confirmation. A T1-weighted image demonstrated a large lipoma that has a central fat-containing region surrounded by an irregular hypointense rim in the inferior portion, confirming the benignity of the lipoma. An ultrasound-guided photoacoustic imaging (PA) of the excised specimen to derive the biochemical distribution demonstrated the “mass-like” hypoechoic regions on US as fat-containing, suggestive of benignity of lesion, rather than fat-replacing suggestive of malignancy. The case showed the potential of PA as an adjunct to US in improving the diagnostic confidence in lesion characterization.
ISSN: 2075-4418
DOI: 10.3390/diagnostics12102456
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