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https://doi.org/10.1158/1078-0432.CCR-21-4179
Title: | Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Postmenopausal Women with Hormone Receptor–Positive Breast Cancer | Authors: | Lim, JSJ Wong, ALA Ow, SGW Ngoi, NYL Chan, GHJ Ang, YLE Chong, WQ Lim, SE Lim, YW Lee, M Choo, JRE Tan, HL Yong, WP Soo, RA Tan, DSP Chee, CE Sundar, R Yadav, K Jain, S Wang, L Tai, BC Goh, BC Lee, SC |
Keywords: | Antineoplastic Combined Chemotherapy Protocols Biomarkers, Tumor Breast Neoplasms Female Humans Letrozole Phenylurea Compounds Postmenopause Quinolines Receptor, ErbB-2 Receptors, Estrogen |
Issue Date: | 1-Jun-2022 | Publisher: | American Association for Cancer Research (AACR) | Citation: | Lim, JSJ, Wong, ALA, Ow, SGW, Ngoi, NYL, Chan, GHJ, Ang, YLE, Chong, WQ, Lim, SE, Lim, YW, Lee, M, Choo, JRE, Tan, HL, Yong, WP, Soo, RA, Tan, DSP, Chee, CE, Sundar, R, Yadav, K, Jain, S, Wang, L, Tai, BC, Goh, BC, Lee, SC (2022-06-01). Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Postmenopausal Women with Hormone Receptor–Positive Breast Cancer. Clinical Cancer Research 28 (11) : 2248-2256. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-21-4179 | Abstract: | Purpose: RET is an estrogen response gene with preclinical studies demonstrating cross-talk between the RET and estrogen receptor (ER) pathways. We investigate the role of lenvatinib, a multikinase inhibitor with potent activity against RET, in patients with metastatic breast cancer. Patients and Methods: Patients with advanced ER+/HER2-breast cancer were treated with lenvatinib plus letrozole in a phase Ib/II trial. Primary objectives included safety and recommended phase II dose (RP2D) determination in phase Ib, and objective response rates (ORR) in phase II dose expansion. Results: Sixteen patients were recruited in dose finding, where deescalating doses of lenvatinib from 20 to 14 mg were investigated. Lenvatinib 14 mg plus letrozole 2.5 mg daily was determined as RP2D. Thirty-one patients with 5 median lines of prior therapy in the metastatic setting (range, 0–11) were recruited in dose expansion. In this cohort, ORR was 23.3% [95% confidence interval (CI) 9.9%–42.3%], with median duration of response (DoR) of 6.9 months [interquartile range (IQR) 5.9 to 13.1]. Clinical benefit rate ≥6 months (CBR) was 50.0% (95% CI, 31.3%–68.7%). Similar efficacy was observed in the subgroup of 25 patients who progressed on prior CDK4/6 inhibitor therapy [ORR 20.0% (95% CI, 6.8%–40.7%), median DoR 6.9 months (IQR 5.9–13.1), and CBR 52.0% (95% CI, 31.3%–72.2%)]. Pharmacodynamic studies showed target modulation, with paired tumor biopsies indicating downregulation of RET/pERK and improved vascular normalization index. Conclusions: Lenvatinib plus letrozole had manageable toxicity, with target engagement and preliminary antitumor activity observed, supporting further assessment in randomized studies. | Source Title: | Clinical Cancer Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/236980 | ISSN: | 1078-0432 1557-3265 |
DOI: | 10.1158/1078-0432.CCR-21-4179 |
Appears in Collections: | Staff Publications Elements |
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