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|Title:||The effects of d-amphetamine on the electrophysiological activity of the superior colliculus in the rat||Authors:||Chee, S.-J.||Keywords:||arousal
|Issue Date:||1991||Citation:||Chee, S.-J. (1991). The effects of d-amphetamine on the electrophysiological activity of the superior colliculus in the rat. Pharmacology Biochemistry and Behavior 40 (2) : 215-220. ScholarBank@NUS Repository.||Abstract:||The superior colliculus (SC) is thought to have an inhibitory effect on arousal (and hence activity) in rats when light is present. d-Amphetamine is believed to suppress this inhibition of the SC on arousal. The present study investigated the electrophysiological activity of the SC of the rat under the influence of d-amphetamine in both light and dark conditions. A single numerical arousal index value (AI) for the electrophysiological data obtained by dividing the frequency of the waves by the voltage over a specified interval was used. Results showed that light conditions decreased the AI of the SC. The AI was, however, not affected by d-amphetamine. Also, the electrophysiological activity of the SC showed spontaneous emissions of high-voltage (600 μV) alpha waves which generally occurred in two- to four-second bursts. Occurrence of this high-voltage activity was reduced by increasing doses of d-amphetamine.||Source Title:||Pharmacology Biochemistry and Behavior||URI:||http://scholarbank.nus.edu.sg/handle/10635/23573||ISSN:||00913057|
|Appears in Collections:||Staff Publications|
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