Please use this identifier to cite or link to this item: https://doi.org/10.1038/tpj.2014.22
Title: Pharmacogenomic diversity in Singaporean populations and Europeans
Authors: Brunham, LR 
Chan, SL
Li, R
Aminkeng, F 
Liu, X
Saw, WY
Ong, RTH 
Pillai, EN 
Carleton, BC
Toh, D
Tan, SH
Koo, SH
Lee, EJD 
Chia, KS
Ross, CJD
Hayden, MR
Sung, C 
Teo, YY
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Pharmacology & Pharmacy
IMPLEMENTATION CONSORTIUM GUIDELINES
CELL LUNG-CANCER
HEARING-LOSS
GENETIC-VARIATION
ASIAN SUBJECTS
ASSOCIATION
DOXORUBICIN
GENOTYPE
PHARMACOKINETICS
VARIANTS
Issue Date: 1-Dec-2014
Publisher: NATURE PUBLISHING GROUP
Citation: Brunham, LR, Chan, SL, Li, R, Aminkeng, F, Liu, X, Saw, WY, Ong, RTH, Pillai, EN, Carleton, BC, Toh, D, Tan, SH, Koo, SH, Lee, EJD, Chia, KS, Ross, CJD, Hayden, MR, Sung, C, Teo, YY (2014-12-01). Pharmacogenomic diversity in Singaporean populations and Europeans. PHARMACOGENOMICS JOURNAL 14 (6) : 555-563. ScholarBank@NUS Repository. https://doi.org/10.1038/tpj.2014.22
Abstract: Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼4500 genetic variants in key drug-biotransformation and -response genes among three South East Asian populations compared with individuals of European ancestry. We compared rates of reported ADRs in these Asian populations to determine if the allelic differentiation corresponded to an excess of the associated ADR. We identified an excess of ADRs related to clopidogrel in Singaporean Chinese, consistent with a higher frequency of a known risk variant in CYP2C19 in that population. We also observed an excess of ADRs related to platinum compounds in Singaporean CHS, despite a very low frequency of known ADR risk variants, suggesting the presence of additional genetic and non-genetic risk factors. Our results point to substantial diversity at specific pharmacogenomic loci that may contribute to inter-population variability in drug response phenotypes.
Source Title: PHARMACOGENOMICS JOURNAL
URI: https://scholarbank.nus.edu.sg/handle/10635/235298
ISSN: 1470-269X
1473-1150
DOI: 10.1038/tpj.2014.22
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