BIOLOGICAL INSIGHTS INTO CORONARY HEART DISEASE VIA OMICS BEYOND THE CENTRAL DOGMA

Abstract

Despite remarkable progress in disease diagnosis and treatment, coronary heart disease (CHD) remains the number one leading cause of death worldwide. Novel and reliable biomarkers are needed to assist in risk assessment, accurate diagnosis and prognosis, and may also act as mediators of disease. For this reason, this multidisciplinary research aims to investigate the translational potential of omics beyond the central dogma (OBCD; comprising metabolomics, lipidomics, glycomics, and metallomics) for CHD. Novel insights into the underlying biological pathways could also be added to the overall omics information trove and advance our understanding of this disease. Hence, this thesis delivers an ensemble of five projects with three overarching phases: (1) a bibliometric study and literature review for the identification of research trends and knowledge gaps in CHD-OBCD, (2) a set of two independent studies and one multi-omics investigation, and (3) novel analytical method development of a bi-omics extraction and analysis workflow.