Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/235015
Title: BIOLOGICAL INSIGHTS INTO CORONARY HEART DISEASE VIA OMICS BEYOND THE CENTRAL DOGMA
Authors: LIM SI YING
ORCID iD:   orcid.org/0000-0003-4250-2837
Keywords: coronary heart disease, multi-omics, metabolomics, lipidomics, glycomics, metallomics
Issue Date: 5-Jul-2022
Citation: LIM SI YING (2022-07-05). BIOLOGICAL INSIGHTS INTO CORONARY HEART DISEASE VIA OMICS BEYOND THE CENTRAL DOGMA. ScholarBank@NUS Repository.
Abstract: Despite remarkable progress in disease diagnosis and treatment, coronary heart disease (CHD) remains the number one leading cause of death worldwide. Novel and reliable biomarkers are needed to assist in risk assessment, accurate diagnosis and prognosis, and may also act as mediators of disease. For this reason, this multidisciplinary research aims to investigate the translational potential of omics beyond the central dogma (OBCD; comprising metabolomics, lipidomics, glycomics, and metallomics) for CHD. Novel insights into the underlying biological pathways could also be added to the overall omics information trove and advance our understanding of this disease. Hence, this thesis delivers an ensemble of five projects with three overarching phases: (1) a bibliometric study and literature review for the identification of research trends and knowledge gaps in CHD-OBCD, (2) a set of two independent studies and one multi-omics investigation, and (3) novel analytical method development of a bi-omics extraction and analysis workflow.
URI: https://scholarbank.nus.edu.sg/handle/10635/235015
Appears in Collections:Ph.D Theses (Restricted)

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