Please use this identifier to cite or link to this item: https://doi.org/10.1002/jcsm.12502
Title: Muscle mass, strength, and physical performance predicting activities of daily living: a meta-analysis
Authors: Wang, Daniel XM
Yao, Jessica
Zirek, Yasar
Reijnierse, Esmee M
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Medicine, General & Internal
General & Internal Medicine
Muscle mass
Muscle strength
Handgrip strength
Physical performance
Activities of daily living
Aged
LOWER-EXTREMITY FUNCTION
DWELLING OLDER MEN
HAND GRIP STRENGTH
USUAL GAIT SPEED
FUNCTIONAL DECLINE
INCIDENT DISABILITY
RISK-FACTORS
INSTRUMENTAL ACTIVITIES
SKELETAL-MUSCLE
SUBSEQUENT DISABILITY
Issue Date: 1-Dec-2019
Publisher: WILEY
Citation: Wang, Daniel XM, Yao, Jessica, Zirek, Yasar, Reijnierse, Esmee M, Maier, Andrea B (2019-12-01). Muscle mass, strength, and physical performance predicting activities of daily living: a meta-analysis. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 11 (1) : Mar-25. ScholarBank@NUS Repository. https://doi.org/10.1002/jcsm.12502
Abstract: Background. Activities of daily living (ADLs) and instrumental activities of daily living (IADLs) are essential for independent living and are predictors of morbidity and mortality in older populations. Older adults who are dependent in ADLs and IADLs are also more likely to have poor muscle measures defined as low muscle mass, muscle strength, and physical performance, which further limit their ability to perform activities. The aim of this systematic review and meta-analysis was to determine if muscle measures are predictive of ADL and IADL in older populations. Methods. A systematic search was conducted using four databases (MEDLINE, EMBASE, Cochrane, and CINAHL) from date of inception to 7 June 2018. Longitudinal cohorts were included that reported baseline muscle measures defined by muscle mass, muscle strength, and physical performance in conjunction with prospective ADL or IADL in participants aged 65 years and older at follow-up. Meta-analyses were conducted using a random effect model. Results. Of the 7760 articles screened, 83 articles were included for the systematic review and involved a total of 108 428 (54.8% female) participants with a follow-up duration ranging from 11 days to 25 years. Low muscle mass was positively associated with ADL dependency in 5/9 articles and 5/5 for IADL dependency. Low muscle strength was associated with ADL dependency in 22/34 articles and IADL dependency in 8/9 articles. Low physical performance was associated with ADL dependency in 37/49 articles and with IADL dependency in 9/11 articles. Forty-five articles were pooled into the meta-analyses, 36 reported ADL, 11 reported IADL, and 2 reported ADL and IADL as a composite outcome. Low muscle mass was associated with worsening ADL (pooled odds ratio (95% confidence interval) 3.19 (1.29–7.92)) and worsening IADL (1.28 (1.02–1.61)). Low handgrip strength was associated with both worsening ADL and IADL (1.51 (1.34–1.70); 1.59 (1.04–2.31) respectively). Low scores on the short physical performance battery and gait speed were associated with worsening ADL (3.49 (2.47–4.92); 2.33 (1.58–3.44) respectively) and IADL (3.09 (1.06–8.98); 1.93 (1.69–2.21) respectively). Low one leg balance (2.74 (1.31–5.72)), timed up and go (3.41 (1.86–6.28)), and chair stand test time (1.90 (1.63–2.21)) were associated with worsening ADL. Conclusions. Muscle measures at baseline are predictors of future ADL and IADL dependence in the older adult population.
Source Title: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
URI: https://scholarbank.nus.edu.sg/handle/10635/234958
ISSN: 2190-5991
2190-6009
DOI: 10.1002/jcsm.12502
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