Please use this identifier to cite or link to this item: https://doi.org/10.1111/acel.13083
Title: Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis
Authors: Tuttle, Camilla SL
Waaijer, Mariette EC
Slee-Valentijn, Monique S
Stijnen, Theo
Westendorp, Rudi
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Geriatrics & Gerontology
aging
cell cycle proteins
cellular senescence
human
immunosenescence
CELLS
EXPRESSION
CLEARANCE
KIDNEYS
GENES
P53
Issue Date: 5-Dec-2019
Publisher: WILEY
Citation: Tuttle, Camilla SL, Waaijer, Mariette EC, Slee-Valentijn, Monique S, Stijnen, Theo, Westendorp, Rudi, Maier, Andrea B (2019-12-05). Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis. AGING CELL 19 (2). ScholarBank@NUS Repository. https://doi.org/10.1111/acel.13083
Abstract: Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta-analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal.
Source Title: AGING CELL
URI: https://scholarbank.nus.edu.sg/handle/10635/234947
ISSN: 1474-9718
1474-9726
DOI: 10.1111/acel.13083
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