Please use this identifier to cite or link to this item:
https://doi.org/10.3109/08830185.2014.921164
DC Field | Value | |
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dc.title | TLR Cross-talk Confers Specificity to Innate Immunity | |
dc.contributor.author | Tan, Rebecca ST | |
dc.contributor.author | Ho, Bow | |
dc.contributor.author | Leung, Bernard P | |
dc.contributor.author | Ding, Jeak L | |
dc.date.accessioned | 2022-11-29T07:26:34Z | |
dc.date.available | 2022-11-29T07:26:34Z | |
dc.date.issued | 2014-11-01 | |
dc.identifier.citation | Tan, Rebecca ST, Ho, Bow, Leung, Bernard P, Ding, Jeak L (2014-11-01). TLR Cross-talk Confers Specificity to Innate Immunity. INTERNATIONAL REVIEWS OF IMMUNOLOGY 33 (6) : 443-453. ScholarBank@NUS Repository. https://doi.org/10.3109/08830185.2014.921164 | |
dc.identifier.issn | 0883-0185 | |
dc.identifier.issn | 1563-5244 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/234920 | |
dc.description.abstract | Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different Toll-like receptor (TLR) ligands leads to quantitatively and qualitatively unique cytokine production, showing that TLR pathway crosstalk enables the innate immune system to orchestrate immediate local and global responses. It is likely that multiple pathways are involved in the regulation of cytokine synergy, including many that have yet to be discovered. | |
dc.language.iso | en | |
dc.publisher | TAYLOR & FRANCIS INC | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Immunology | |
dc.subject | cytokines | |
dc.subject | macrophage | |
dc.subject | pathogen recognition | |
dc.subject | signaling cross-talk | |
dc.subject | toll-like receptors | |
dc.subject | INDUCED INTERLEUKIN-12P70 SECRETION | |
dc.subject | TOLL-LIKE RECEPTORS | |
dc.subject | DENDRITIC CELLS | |
dc.subject | CYTOKINE PRODUCTION | |
dc.subject | ADAPTIVE IMMUNITY | |
dc.subject | GENE-EXPRESSION | |
dc.subject | PATHWAYS | |
dc.subject | ACTIVATION | |
dc.subject | TOLERANCE | |
dc.subject | RESPONSES | |
dc.type | Review | |
dc.date.updated | 2022-11-29T03:20:08Z | |
dc.contributor.department | BIOLOGY (NU) | |
dc.contributor.department | FOOD SCIENCE & TECHNOLOGY | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.3109/08830185.2014.921164 | |
dc.description.sourcetitle | INTERNATIONAL REVIEWS OF IMMUNOLOGY | |
dc.description.volume | 33 | |
dc.description.issue | 6 | |
dc.description.page | 443-453 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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IRI_(TLR crosstalks confers...) Tan et al_2014.pdf | Published version | 152.38 kB | Adobe PDF | OPEN | Published | View/Download |
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