Please use this identifier to cite or link to this item: https://doi.org/10.3109/08830185.2014.921164
Title: TLR Cross-talk Confers Specificity to Innate Immunity
Authors: Tan, Rebecca ST
Ho, Bow 
Leung, Bernard P 
Ding, Jeak L 
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
cytokines
macrophage
pathogen recognition
signaling cross-talk
toll-like receptors
INDUCED INTERLEUKIN-12P70 SECRETION
TOLL-LIKE RECEPTORS
DENDRITIC CELLS
CYTOKINE PRODUCTION
ADAPTIVE IMMUNITY
GENE-EXPRESSION
PATHWAYS
ACTIVATION
TOLERANCE
RESPONSES
Issue Date: 1-Nov-2014
Publisher: TAYLOR & FRANCIS INC
Citation: Tan, Rebecca ST, Ho, Bow, Leung, Bernard P, Ding, Jeak L (2014-11-01). TLR Cross-talk Confers Specificity to Innate Immunity. INTERNATIONAL REVIEWS OF IMMUNOLOGY 33 (6) : 443-453. ScholarBank@NUS Repository. https://doi.org/10.3109/08830185.2014.921164
Abstract: Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different Toll-like receptor (TLR) ligands leads to quantitatively and qualitatively unique cytokine production, showing that TLR pathway crosstalk enables the innate immune system to orchestrate immediate local and global responses. It is likely that multiple pathways are involved in the regulation of cytokine synergy, including many that have yet to be discovered.
Source Title: INTERNATIONAL REVIEWS OF IMMUNOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/234920
ISSN: 0883-0185
1563-5244
DOI: 10.3109/08830185.2014.921164
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