Please use this identifier to cite or link to this item: https://doi.org/10.1089/dna.2014.2639
Title: The Unexplored Roles of Human Serum IgA
Authors: Leong, Ka Wai 
Ding, Jeak Ling 
Keywords: Adaptive Immunity
Animals
Glycosylation
Humans
Immunoglobulin A
Intestinal Mucosa
Leukocytes
Lupus Erythematosus, Systemic
Protein Binding
Protein Processing, Post-Translational
Issue Date: 1-Dec-2014
Publisher: Mary Ann Liebert Inc
Citation: Leong, Ka Wai, Ding, Jeak Ling (2014-12-01). The Unexplored Roles of Human Serum IgA. DNA AND CELL BIOLOGY 33 (12) : 823-829. ScholarBank@NUS Repository. https://doi.org/10.1089/dna.2014.2639
Abstract: The roles of human serum IgA, in contrast to that of mucosal IgA, are relatively unexplored. Previous studies have shown that IgA mediates either pro- or anti-inflammatory effects in innate immune cells. Serum IgA has been shown to interact with many proteins and glycoproteins of which the functions and mechanisms are not fully characterized. Here, we present fresh perspectives into the roles of serum IgA, describing novel IgA-protein interactions, the importance of its glycosylation status in normal functions, and the plausible role of IgA as a driver and regulator of autoimmune diseases/immune overactivation. Other potential roles, including the regulation of cytokines, effector cell function, and homeostasis, are considered in view of the maintenance of immune function. We anticipate future research to uncover new anti-inflammatory or pro-inflammatory roles of human serum IgA in immune functions and dysfunctions, with implications on systemic lupus erythematosus (SLE).
Source Title: DNA AND CELL BIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/234915
ISSN: 1044-5498
1557-7430
DOI: 10.1089/dna.2014.2639
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