Please use this identifier to cite or link to this item: https://doi.org/10.1093/infdis/jiaa480
Title: Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults
Authors: Chen, Sijia
Pawelec, Graham
Trompet, Stella
Goldeck, David
Mortensen, Laust H
Slagboom, P Eline
Christensen, Kaare
Gussekloo, Jacobijn
Kearney, Patricia
Buckley, Brendan M
Ford, Ian
Jukema, J Wouter
Westendorp, Rudi GJ
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Herpesviridae
cytomegalovirus
seroepidemiologic studies
immunoglobulin G
mortality
cardiovascular
aged
C-REACTIVE PROTEIN
G ANTIBODY-LEVELS
CMV INFECTION
HEART-DISEASE
RISK-FACTORS
SEROPOSITIVITY
INFLAMMATION
SURVIVAL
PRAVASTATIN
FRAILTY
Issue Date: 15-Jan-2021
Publisher: OXFORD UNIV PRESS INC
Citation: Chen, Sijia, Pawelec, Graham, Trompet, Stella, Goldeck, David, Mortensen, Laust H, Slagboom, P Eline, Christensen, Kaare, Gussekloo, Jacobijn, Kearney, Patricia, Buckley, Brendan M, Ford, Ian, Jukema, J Wouter, Westendorp, Rudi GJ, Maier, Andrea B (2021-01-15). Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. JOURNAL OF INFECTIOUS DISEASES 223 (2) : 238-246. ScholarBank@NUS Repository. https://doi.org/10.1093/infdis/jiaa480
Abstract: Background: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. Methods: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up. Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. Results: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI],. 97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI,. 83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI,. 99-1.29). The lack of increased mortality risk was confirmed in subanalyses. Conclusions: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.
Source Title: JOURNAL OF INFECTIOUS DISEASES
URI: https://scholarbank.nus.edu.sg/handle/10635/234883
ISSN: 0022-1899
1537-6613
DOI: 10.1093/infdis/jiaa480
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