Please use this identifier to cite or link to this item: https://doi.org/10.1136/bmjopen-2021-054950
Title: Combating sarcopenia in geriatric rehabilitation patients: study protocol of the EMPOWER-GR observational cohort, sarcopenia awareness survey and randomised controlled feasibility trial
Authors: Verstraeten, Laure MG
van Wijngaarden, Janneke P
Tol-Schilder, Marina
Meskers, Carel GM
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
rehabilitation medicine
geriatric medicine
nutrition & dietetics
MUSCLE PROTEIN-SYNTHESIS
OLDER-ADULTS
WHEY-PROTEIN
DOUBLE-BLIND
VITAMIN-D
NUTRITIONAL SUPPLEMENT
HANDGRIP STRENGTH
SARC-F
MALNUTRITION
MORTALITY
Issue Date: 1-Mar-2022
Publisher: BMJ PUBLISHING GROUP
Citation: Verstraeten, Laure MG, van Wijngaarden, Janneke P, Tol-Schilder, Marina, Meskers, Carel GM, Maier, Andrea B (2022-03-01). Combating sarcopenia in geriatric rehabilitation patients: study protocol of the EMPOWER-GR observational cohort, sarcopenia awareness survey and randomised controlled feasibility trial. BMJ OPEN 12 (3). ScholarBank@NUS Repository. https://doi.org/10.1136/bmjopen-2021-054950
Abstract: Introduction Sarcopenia is highly prevalent in geriatric rehabilitation patients. Resistance exercise training (RET) combined with protein supplementation is recommended to increase muscle mass and strength in older adults. However, sarcopenia awareness, feasibility to diagnose and treat sarcopenia, and efficacy of treatment in geriatric rehabilitation patients remain to be established. Methods and analysis Enhancing Muscle POWER in Geriatric Rehabilitation (EMPOWER-GR) encompasses four pillars: (1) an observational cohort study of 200 geriatric rehabilitation inpatients determining sarcopenia prevalence, functional and nutritional status at admission; (2) a survey among these 200 patients and 500 healthcare professionals and semistructured interviews in 30 patients and 15 carers determining sarcopenia awareness and barriers/enablers regarding diagnostics and treatment; (3) a feasibility, single-centre, randomised, controlled, open-label, two parallel-group trial in 80 geriatric rehabilitation patients with sarcopenia. The active group (n=40) receives three RET sessions per week and a leucine and vitamin D-enriched whey protein-based oral nutritional supplement two times per day in combination with usual care for 13 weeks. The control group (n=40) receives usual care. Primary outcomes are feasibility (adherence to the intervention, dropout rate, overall feasibility) and change from baseline in absolute muscle mass at discharge and week 13. Secondary outcomes are feasibility (participation rate) and change from baseline at discharge and week 13 in relative muscle mass, muscle strength, physical and functional performance, mobility, nutritional status, dietary intake, quality of life and length of stay; institutionalisation and hospitalisation at 6 months and mortality at 6 months and 2 years; (4) knowledge sharing on sarcopenia diagnosis and treatment. Ethics and dissemination Ethical exemption was received for the observational cohort study, ethics approval was received for the randomised controlled trial. Results will be disseminated through publications in scientific peer-reviewed journals, conferences and social media. Trial registration number NL9444.
Source Title: BMJ OPEN
URI: https://scholarbank.nus.edu.sg/handle/10635/234870
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2021-054950
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