Please use this identifier to cite or link to this item: https://doi.org/10.1007/s41999-022-00625-5
Title: Albumin and C-reactive protein relate to functional and body composition parameters in patients admitted to geriatric rehabilitation after acute hospitalization: findings from the RESORT cohort
Authors: Van Ancum, Jeanine M
Tuttle, Camilla SL
Koopman, Rene
Pijnappels, Mirjam
Meskers, Carel GM
Paul, Sanjoy K
Lim, Wen Kwang
Reijnierse, Esmee M
Lynch, Gordon S
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Inflammation
Activities of daily living
Physical functional performance
Muscle strength
Sarcopenia
MUSCLE MASS
SERUM-ALBUMIN
SYSTEMIC INFLAMMATION
STRENGTH
SARCOPENIA
HEALTH
MALNUTRITION
PERFORMANCE
METABOLISM
DISABILITY
Issue Date: 2-Mar-2022
Publisher: SPRINGER
Citation: Van Ancum, Jeanine M, Tuttle, Camilla SL, Koopman, Rene, Pijnappels, Mirjam, Meskers, Carel GM, Paul, Sanjoy K, Lim, Wen Kwang, Reijnierse, Esmee M, Lynch, Gordon S, Maier, Andrea B (2022-03-02). Albumin and C-reactive protein relate to functional and body composition parameters in patients admitted to geriatric rehabilitation after acute hospitalization: findings from the RESORT cohort. EUROPEAN GERIATRIC MEDICINE 13 (3) : 623-632. ScholarBank@NUS Repository. https://doi.org/10.1007/s41999-022-00625-5
Abstract: Purpose: Albumin and C-reactive protein (CRP) are non-specific markers of inflammation, which could affect muscle tissue during acute hospitalization. We investigated the association between albumin and CRP during acute hospitalization with functional and body composition parameters in patients admitted to geriatric rehabilitation. Methods: The REStORing Health of Acutely Unwell AdulTs (RESORT) cohort includes geriatric rehabilitation patients assessed for change in activities of daily living (ADL, using the Katz index) during acute hospitalization, and subsequently for Katz ADL, gait speed (GS), handgrip strength (HGS) and skeletal muscle mass index (SMI) at geriatric rehabilitation admission. Albumin and CRP average (median), variation (interquartile range), and maximum or minimum were collected from serum samples, and were examined for their association with functional and body composition parameters using multivariable linear regression analysis adjusted for age, sex and length of acute hospital stay. Results: 1769 Inpatients were included for analyses (mean age 82.6 years ± 8.1, 56% female). Median length of acute hospitalization was 7 [IQR 4, 13] days and median number of albumin and CRP measurements was 5 [IQR 3, 12] times. ADL declined in 89% of patients (median − 3 points, IQR − 4, − 2). Lower average albumin, higher albumin variation and lower minimum albumin were associated with larger declines in ADL and with lower ADL, GS, HGS and SMI at geriatric rehabilitation admission. Higher average and maximum CRP were associated with lower GS. Conclusion: Inflammation, especially lower albumin concentrations, during acute hospitalization is associated with lower physical function at geriatric rehabilitation admission.
Source Title: EUROPEAN GERIATRIC MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/234868
ISSN: 1878-7649
1878-7657
DOI: 10.1007/s41999-022-00625-5
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