Please use this identifier to cite or link to this item: https://doi.org/10.4254/wjh.v14.i6.1235
Title: Factors early in life associated with hepatic steatosis
Authors: Quek, SXZ
Tan, EXX 
Ren, YP
Muthiah, M 
Loo, EXL 
Tham, EH 
Siah, KTH
Keywords: Developmental
Epidemiology
Fatty liver
Natural history
Obesity
Issue Date: 27-Jun-2022
Publisher: Baishideng Publishing Group Inc.
Citation: Quek, SXZ, Tan, EXX, Ren, YP, Muthiah, M, Loo, EXL, Tham, EH, Siah, KTH (2022-06-27). Factors early in life associated with hepatic steatosis. World Journal of Hepatology 14 (6) : 1235-1247. ScholarBank@NUS Repository. https://doi.org/10.4254/wjh.v14.i6.1235
Abstract: BACKGROUND The rise in prevalence of non-alcoholic fatty liver disease (NAFLD) mirrors the obesity epidemic. NAFLD is insidious but may gradually progress from simple steatosis to steatohepatitis, fibrosis and cirrhosis and/or hepatocellular carcinoma. Intervention strategies to ameliorate developmental programming of NAFLD may be more efficacious during critical windows of developmental plasticity. AIM To review the early developmental factors associated with NAFLD. METHODS Databases MEDLINE via PubMed, and EMBASE and Reference Citation Analysis were searched and relevant publications up to April 30, 2021 were assessed. Original research studies that included risk factors associated with early development of NAFLD in human subjects were included. These factors include: Maternal factors, intrauterine and prenatal factors, post-natal factors, genetic and ethnic predisposition, childhood and adolescence environmental factors. Studies were excluded if they were review articles or animal studies, case reports or conference abstracts, or if NAFLD was not clearly defined and assessed radiologically. RESULTS Of 1530 citations identified by electronic search, 420 duplicates were removed. Of the 1110 citations screened from title and abstract, 80 articles were included in the final analysis. Genetic polymorphisms such as patatin-like phospholipase domain-containing protein 3 (PNPLA3) and membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) were associated with increased risk of NAFLD. Familial factors such as maternal obesogenic environment and parental history of hepatic steatosis was associated with offspring NAFLD. Longer duration of exclusive breastfeeding in infancy was associated with a lower risk of developing NAFLD later in life while metabolic dysfunction and/or obesity in adolescence was associated with increased risk of NAFLD. Studies relating to socioeconomic factors and its association with NAFLD reported confounding results. CONCLUSION Maternal metabolic dysfunction during pregnancy, being exclusively breastfed for a longer time postnatally, diet and physical activity in childhood and adolescence are potential areas of intervention to decrease risk of NAFLD
Source Title: World Journal of Hepatology
URI: https://scholarbank.nus.edu.sg/handle/10635/234861
ISSN: 1948-5182
DOI: 10.4254/wjh.v14.i6.1235
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Factors early in life associated with hepatic steatosis.pdf613.41 kBAdobe PDF

OPEN

PublishedView/Download

Page view(s)

17
checked on Feb 2, 2023

Download(s)

6
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.