Please use this identifier to cite or link to this item:
https://doi.org/10.1002/btm2.10293
DC Field | Value | |
---|---|---|
dc.title | Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants | |
dc.contributor.author | Lim, Sing Mei | |
dc.contributor.author | Cheng, Hoi Lok | |
dc.contributor.author | Jia, Huan | |
dc.contributor.author | Kongsuphol, Patthara | |
dc.contributor.author | Shunmuganathan, Bhuvaneshwari | |
dc.contributor.author | Chen, Ming Wei | |
dc.contributor.author | Ng, Say Yong | |
dc.contributor.author | Gao, Xiaohong | |
dc.contributor.author | Turaga, Shuvan Prashant | |
dc.contributor.author | Heussler, Sascha P | |
dc.contributor.author | Somani, Jyoti | |
dc.contributor.author | Sengupta, Sharmila | |
dc.contributor.author | Tay, Dousabel MY | |
dc.contributor.author | McBee, Megan E | |
dc.contributor.author | Young, Barnaby E | |
dc.contributor.author | MacAry, Paul A | |
dc.contributor.author | Sikes, Hadley D | |
dc.contributor.author | Preiser, Peter R | |
dc.date.accessioned | 2022-11-21T09:02:59Z | |
dc.date.available | 2022-11-21T09:02:59Z | |
dc.date.issued | 2022-02-10 | |
dc.identifier.citation | Lim, Sing Mei, Cheng, Hoi Lok, Jia, Huan, Kongsuphol, Patthara, Shunmuganathan, Bhuvaneshwari, Chen, Ming Wei, Ng, Say Yong, Gao, Xiaohong, Turaga, Shuvan Prashant, Heussler, Sascha P, Somani, Jyoti, Sengupta, Sharmila, Tay, Dousabel MY, McBee, Megan E, Young, Barnaby E, MacAry, Paul A, Sikes, Hadley D, Preiser, Peter R (2022-02-10). Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants. BIOENGINEERING & TRANSLATIONAL MEDICINE 7 (2). ScholarBank@NUS Repository. https://doi.org/10.1002/btm2.10293 | |
dc.identifier.issn | 2380-6761 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/234733 | |
dc.description.abstract | There is clinical need for a quantifiable point-of-care (PoC) SARS-CoV-2 neutralizing antibody (nAb) test that is adaptable with the pandemic's changing landscape. Here, we present a rapid and semi-quantitative nAb test that uses finger stick or venous blood to assess the nAb response of vaccinated population against wild-type (WT), alpha, beta, gamma, and delta variant RBDs. It captures a clinically relevant range of nAb levels, and effectively differentiates prevaccination, post first dose, and post second dose vaccination samples within 10 min. The data observed against alpha, beta, gamma, and delta variants agrees with published results evaluated in established serology tests. Finally, our test revealed a substantial reduction in nAb level for beta, gamma, and delta variants between early BNT162b2 vaccination group (within 3 months) and later vaccination group (post 3 months). This test is highly suited for PoC settings and provides an insightful nAb response in a postvaccinated population. | |
dc.language.iso | en | |
dc.publisher | WILEY | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Technology | |
dc.subject | Biotechnology & Applied Microbiology | |
dc.subject | Engineering, Biomedical | |
dc.subject | Pharmacology & Pharmacy | |
dc.subject | Engineering | |
dc.subject | cellulose pulldown assay | |
dc.subject | COVID19 | |
dc.subject | humoral response against COVID19 variants | |
dc.subject | neutralizing antibody | |
dc.subject | point-of-care test | |
dc.subject | SARS-CoV-2 | |
dc.subject | serology test | |
dc.subject | VACCINE | |
dc.type | Article | |
dc.date.updated | 2022-11-19T06:35:37Z | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | SINGAPORE SYNCHROTRON LIGHT SOURCE | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1002/btm2.10293 | |
dc.description.sourcetitle | BIOENGINEERING & TRANSLATIONAL MEDICINE | |
dc.description.volume | 7 | |
dc.description.issue | 2 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants.pdf | 7.89 MB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.