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https://doi.org/10.3390/v13081507
Title: | Animal coronavirus diseases: Parallels with COVID-19 in humans | Authors: | Lin, Chao-Nan Chan, Kuan Rong Ooi, Eng Eong Chiou, Ming-Tang Hoang, Minh Hsueh, Po-Ren Ooi, Peck Toung |
Keywords: | Animal coronavirus COVID-19 DIVA Immunopathogenesis |
Issue Date: | 30-Jul-2021 | Publisher: | MDPI AG | Citation: | Lin, Chao-Nan, Chan, Kuan Rong, Ooi, Eng Eong, Chiou, Ming-Tang, Hoang, Minh, Hsueh, Po-Ren, Ooi, Peck Toung (2021-07-30). Animal coronavirus diseases: Parallels with COVID-19 in humans. Viruses 13 (8) : 1507. ScholarBank@NUS Repository. https://doi.org/10.3390/v13081507 | Rights: | Attribution 4.0 International | Abstract: | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coro-navirus 2 (SARS-CoV-2), a novel coronavirus in humans, has expanded globally over the past year. COVID-19 remains an important subject of intensive research owing to its huge impact on economic and public health globally. Based on historical archives, the first coronavirus-related disease rec-orded was possibly animal-related, a case of feline infectious peritonitis described as early as 1912. Despite over a century of documented coronaviruses in animals, the global animal industry still suffers from outbreaks. Knowledge and experience handling animal coronaviruses provide a valuable tool to complement our understanding of the ongoing COVID-19 pandemic. In this review, we present an overview of coronaviruses, clinical signs, COVID-19 in animals, genome organization and recombination, immunopathogenesis, transmission, viral shedding, diagnosis, treatment, and prevention. By drawing parallels between COVID-19 in animals and humans, we provide perspectives on the pathophysiological mechanisms by which coronaviruses cause diseases in both animals and humans, providing a critical basis for the development of effective vaccines and therapeutics against these deadly viruses. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | Source Title: | Viruses | URI: | https://scholarbank.nus.edu.sg/handle/10635/233674 | ISSN: | 1999-4915 | DOI: | 10.3390/v13081507 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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