Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.celrep.2021.109969
Title: MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response
Authors: Yee Mon, Kristel J.
Zhu, Hongya
Daly, Ciaran W. P.
Vu, Luyen T. 
Smith, Norah L.
Patel, Ravi
Topham, David J.
Scheible, Kristin
Jambo, Kondwani
Le, Minh T. N. 
Rudd, Brian D.
Grimson, Andrew
Keywords: activation threshold
adaptive immunity
CD8+ T cell
extracellular vesicle
gene regulation
immunological memory
microRNA
miR-29
naive
neonate
Issue Date: 1-Nov-2021
Publisher: Elsevier B.V.
Citation: Yee Mon, Kristel J., Zhu, Hongya, Daly, Ciaran W. P., Vu, Luyen T., Smith, Norah L., Patel, Ravi, Topham, David J., Scheible, Kristin, Jambo, Kondwani, Le, Minh T. N., Rudd, Brian D., Grimson, Andrew (2021-11-01). MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response. Cell Reports 37 (6) : 109969. ScholarBank@NUS Repository. https://doi.org/10.1016/j.celrep.2021.109969
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults. © 2021 The Authors
Source Title: Cell Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/233613
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2021.109969
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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