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dc.titleAge-seroprevalence curves for the multi-strain structure of influenza A virus
dc.contributor.authorDao Nguyen Vinh
dc.contributor.authorNguyen Thi Duy Nhat
dc.contributor.authorde Bruin, Erwin
dc.contributor.authorNguyen Ha Thao Vy
dc.contributor.authorTran Thi Nhu Thao
dc.contributor.authorHuynh Thi Phuong
dc.contributor.authorPham Hong Anh
dc.contributor.authorTodd, Stacy
dc.contributor.authorTran Minh Quan
dc.contributor.authorNguyen Thi Le Thanh
dc.contributor.authorNguyen Thi Nam Lien
dc.contributor.authorNguyen Thi Hong Ha
dc.contributor.authorTran Thi Kim Hong
dc.contributor.authorPham Quang Thai
dc.contributor.authorChoisy, Marc
dc.contributor.authorTran Dang Nguyen
dc.contributor.authorSimmons, Cameron P.
dc.contributor.authorThwaites, Guy E.
dc.contributor.authorClapham, Hannah E.
dc.contributor.authorNguyen Van Vinh Chau
dc.contributor.authorKoopmans, Marion
dc.contributor.authorBoni, Maciej F.
dc.identifier.citationDao Nguyen Vinh, Nguyen Thi Duy Nhat, de Bruin, Erwin, Nguyen Ha Thao Vy, Tran Thi Nhu Thao, Huynh Thi Phuong, Pham Hong Anh, Todd, Stacy, Tran Minh Quan, Nguyen Thi Le Thanh, Nguyen Thi Nam Lien, Nguyen Thi Hong Ha, Tran Thi Kim Hong, Pham Quang Thai, Choisy, Marc, Tran Dang Nguyen, Simmons, Cameron P., Thwaites, Guy E., Clapham, Hannah E., Nguyen Van Vinh Chau, Koopmans, Marion, Boni, Maciej F. (2021-11-18). Age-seroprevalence curves for the multi-strain structure of influenza A virus. Nature Communications 12 (1) : 6680. ScholarBank@NUS Repository.
dc.description.abstractThe relationship between age and seroprevalence can be used to estimate the annual attack rate of an infectious disease. For pathogens with multiple serologically distinct strains, there is a need to describe composite exposure to an antigenically variable group of pathogens. In this study, we assay 24,402 general-population serum samples, collected in Vietnam between 2009 to 2015, for antibodies to eleven human influenza A strains. We report that a principal components decomposition of antibody titer data gives the first principal component as an appropriate surrogate for seroprevalence; this results in annual attack rate estimates of 25.6% (95% CI: 24.1% – 27.1%) for subtype H3 and 16.0% (95% CI: 14.7% – 17.3%) for subtype H1. The remaining principal components separate the strains by serological similarity and associate birth cohorts with their particular influenza histories. Our work shows that dimensionality reduction can be used on human antibody profiles to construct an age-seroprevalence relationship for antigenically variable pathogens. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.sourcetitleNature Communications
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