Please use this identifier to cite or link to this item:
https://doi.org/10.3390/cells10123570
DC Field | Value | |
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dc.title | Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms | |
dc.contributor.author | Wang, Qin-Qi | |
dc.contributor.author | Yin, Gang | |
dc.contributor.author | Huang, Jiang-Rong | |
dc.contributor.author | Xi, Shi-Jun | |
dc.contributor.author | Qian, Feng | |
dc.contributor.author | Lee, Rui-Xue | |
dc.contributor.author | Peng, Xiao-Chun | |
dc.contributor.author | Tang, Feng-Ru | |
dc.date.accessioned | 2022-10-26T08:59:45Z | |
dc.date.available | 2022-10-26T08:59:45Z | |
dc.date.issued | 2021-12-17 | |
dc.identifier.citation | Wang, Qin-Qi, Yin, Gang, Huang, Jiang-Rong, Xi, Shi-Jun, Qian, Feng, Lee, Rui-Xue, Peng, Xiao-Chun, Tang, Feng-Ru (2021-12-17). Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms. Cells 10 (12) : 3570. ScholarBank@NUS Repository. https://doi.org/10.3390/cells10123570 | |
dc.identifier.issn | 2073-4409 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/233525 | |
dc.description.abstract | Population aging is occurring rapidly worldwide, challenging the global economy and healthcare services. Brain aging is a significant contributor to various age-related neurological and neuropsychological disorders, including Alzheimer’s disease and Parkinson’s disease. Several ex-trinsic factors, such as exposure to ionizing radiation, can accelerate senescence. Multiple human and animal studies have reported that exposure to ionizing radiation can have varied effects on organ aging and lead to the prolongation or shortening of life span depending on the radiation dose or dose rate. This paper reviews the effects of radiation on the aging of different types of brain cells, including neurons, microglia, astrocytes, and cerebral endothelial cells. Further, the relevant molecular mechanisms are discussed. Overall, this review highlights how radiation-induced senescence in different cell types may lead to brain aging, which could result in the development of various neurological and neuropsychological disorders. Therefore, treatment targeting radiation-induced oxidative stress and neuroinflammation may prevent radiation-induced brain aging and the neurological and neuropsychological disorders it may cause. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.publisher | MDPI | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | Aging | |
dc.subject | Brain | |
dc.subject | DNA damage | |
dc.subject | Ionizing radiation | |
dc.subject | Mitochondrial dysfunction | |
dc.subject | Oxidative stress | |
dc.type | Review | |
dc.contributor.department | S'PORE NUCLEAR RSCH & SAFETY INITIATIVE | |
dc.description.doi | 10.3390/cells10123570 | |
dc.description.sourcetitle | Cells | |
dc.description.volume | 10 | |
dc.description.issue | 12 | |
dc.description.page | 3570 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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