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Title: Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms
Authors: Wang, Qin-Qi
Yin, Gang
Huang, Jiang-Rong
Xi, Shi-Jun
Qian, Feng
Lee, Rui-Xue 
Peng, Xiao-Chun
Tang, Feng-Ru 
Keywords: Aging
DNA damage
Ionizing radiation
Mitochondrial dysfunction
Oxidative stress
Issue Date: 17-Dec-2021
Publisher: MDPI
Citation: Wang, Qin-Qi, Yin, Gang, Huang, Jiang-Rong, Xi, Shi-Jun, Qian, Feng, Lee, Rui-Xue, Peng, Xiao-Chun, Tang, Feng-Ru (2021-12-17). Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms. Cells 10 (12) : 3570. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Population aging is occurring rapidly worldwide, challenging the global economy and healthcare services. Brain aging is a significant contributor to various age-related neurological and neuropsychological disorders, including Alzheimer’s disease and Parkinson’s disease. Several ex-trinsic factors, such as exposure to ionizing radiation, can accelerate senescence. Multiple human and animal studies have reported that exposure to ionizing radiation can have varied effects on organ aging and lead to the prolongation or shortening of life span depending on the radiation dose or dose rate. This paper reviews the effects of radiation on the aging of different types of brain cells, including neurons, microglia, astrocytes, and cerebral endothelial cells. Further, the relevant molecular mechanisms are discussed. Overall, this review highlights how radiation-induced senescence in different cell types may lead to brain aging, which could result in the development of various neurological and neuropsychological disorders. Therefore, treatment targeting radiation-induced oxidative stress and neuroinflammation may prevent radiation-induced brain aging and the neurological and neuropsychological disorders it may cause. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Cells
ISSN: 2073-4409
DOI: 10.3390/cells10123570
Rights: Attribution 4.0 International
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