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Title: Plasma acylcarnitines during pregnancy and neonatal anthropometry: A longitudinal study in a multiracial cohort
Authors: Song, Yiqing
Lyu, Chen
Li, Ming
Rahman, Mohammad L.
Chen, Zhen
Zhu, Yeyi
Hinkle, Stefanie N.
Chen, Liwei
Mitro, Susanna D.
Li, Ling-Jun 
Weir, Natalie L.
Tsai, Michael Y.
Zhang, Cuilin
Keywords: Acylcarnitine
Body length
Gestational weeks
Neonatal anthropometry
Sum of body circumference
Sum of skinfolds
Issue Date: 17-Dec-2021
Publisher: MDPI
Citation: Song, Yiqing, Lyu, Chen, Li, Ming, Rahman, Mohammad L., Chen, Zhen, Zhu, Yeyi, Hinkle, Stefanie N., Chen, Liwei, Mitro, Susanna D., Li, Ling-Jun, Weir, Natalie L., Tsai, Michael Y., Zhang, Cuilin (2021-12-17). Plasma acylcarnitines during pregnancy and neonatal anthropometry: A longitudinal study in a multiracial cohort. Metabolites 11 (12) : 885. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: As surrogate readouts reflecting mitochondrial dysfunction, elevated levels of plasma acylcarnitines have been associated with cardiometabolic disorders, such as obesity, gestational diabetes, and type 2 diabetes. This study aimed to examine prospective associations of acylcarnitine profiles across gestation with neonatal anthropometry, including birthweight, birthweight z score, body length, sum of skinfolds, and sum of body circumferences. We quantified 28 acylcarnitines using electrospray ionization tandem mass spectrometry in plasma collected at gestational weeks 10–14, 15–26, 23–31, and 33–39 among 321 pregnant women from the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons. A latent-class trajectory approach was applied to identify trajectories of acylcarnitines across gestation. We examined the associations of individual acylcarnitines and distinct trajectory groups with neonatal anthropometry using weighted generalized linear models adjusting for maternal age, race/ethnicity, education, parity, gestational age at blood collection, and pre-pregnancy body mass index (BMI). We identified three distinct trajectory groups in C2, C3, and C4 and two trajectory groups in C5, C10, C5–DC, C8:1, C10:1, and C12, respectively. Women with nonlinear decreasing C12 levels across gestation (5.7%) had offspring with significantly lower birthweight (?475 g; 95% CI, ?942, ?6.79), birthweight z score (?0.39, ?0.71, ?0.06), and birth length (?1.38 cm, ?2.49, ?0.27) than those with persistently stable C12 levels (94.3%) (all nominal p value < 0.05). Women with consistently higher levels of C10 (6.1%) had offspring with thicker sum of skinfolds (4.91 mm, 0.85, 8.98) than did women with lower levels (93.9%) during pregnancy, whereas women with lower C10:1 levels (12.6%) had offspring with thicker sum of skinfolds (3.23 mm, 0.19, 6.27) than did women with abruptly increasing levels (87.4%) (p < 0.05). In conclusion, this study suggests that distinctive trajectories of C10, C10:1, and C12 acylcarnitine levels throughout pregnancy were significantly associated with neonatal anthropometry. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Metabolites
ISSN: 2218-1989
DOI: 10.3390/metabo11120885
Rights: Attribution 4.0 International
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