Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41418-021-00798-9
DC Field | Value | |
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dc.title | Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3 | |
dc.contributor.author | Tang, Peng | |
dc.contributor.author | Virtue, Sam | |
dc.contributor.author | Goie, Jian Yi Gerald | |
dc.contributor.author | Png, Chin Wen | |
dc.contributor.author | Guo, Jing | |
dc.contributor.author | Li, Ying | |
dc.contributor.author | Jiao, Huipeng | |
dc.contributor.author | Chua, Yen Leong | |
dc.contributor.author | Campbell, Mark | |
dc.contributor.author | Moreno-Navarrete, Jose Maria | |
dc.contributor.author | Shabbir, Asim | |
dc.contributor.author | Fernández-Real, J.-M. | |
dc.contributor.author | Gasser, Stephan | |
dc.contributor.author | Kemeny, David Michael | |
dc.contributor.author | Yang, Henry | |
dc.contributor.author | Vidal-Puig, Antonio | |
dc.contributor.author | Zhang, Yongliang | |
dc.date.accessioned | 2022-10-13T07:59:19Z | |
dc.date.available | 2022-10-13T07:59:19Z | |
dc.date.issued | 2021-06-05 | |
dc.identifier.citation | Tang, Peng, Virtue, Sam, Goie, Jian Yi Gerald, Png, Chin Wen, Guo, Jing, Li, Ying, Jiao, Huipeng, Chua, Yen Leong, Campbell, Mark, Moreno-Navarrete, Jose Maria, Shabbir, Asim, Fernández-Real, J.-M., Gasser, Stephan, Kemeny, David Michael, Yang, Henry, Vidal-Puig, Antonio, Zhang, Yongliang (2021-06-05). Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death and Differentiation 28 (11) : 3022-3035. ScholarBank@NUS Repository. https://doi.org/10.1038/s41418-021-00798-9 | |
dc.identifier.issn | 1350-9047 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/233292 | |
dc.description.abstract | Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the role of IRF3 in obesity and obesity-associated disorders remains unclear. Here, we show that IRF3 expression in human adipose tissues is positively associated with insulin sensitivity and negatively associated with type 2 diabetes. In mouse pre-adipocytes, deficiency of IRF3 results in increased expression of PPAR? and PPAR?-mediated adipogenic genes, leading to increased adipogenesis and altered adipocyte functionality. The IRF3 knockout (KO) mice develop obesity, insulin resistance, glucose intolerance, and eventually type 2 diabetes with aging, which is associated with the development of white adipose tissue (WAT) inflammation. Increased macrophage accumulation with M1 phenotype which is due to the loss of IFN?-mediated IL-10 expression is observed in WAT of the KO mice compared to that in wild-type mice. Bone-marrow reconstitution experiments demonstrate that the nonhematopoietic cells are the primary contributors to the development of obesity and both hematopoietic and nonhematopoietic cells contribute to the development of obesity-related complications in IRF3 KO mice. This study demonstrates that IRF3 regulates the biology of multiple cell types including adipocytes and macrophages to prevent the development of obesity and obesity-related complications and hence, could be a potential target for therapeutic interventions for the prevention and treatment of obesity-associated metabolic disorders. © 2021, The Author(s). | |
dc.publisher | Springer Nature | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.1038/s41418-021-00798-9 | |
dc.description.sourcetitle | Cell Death and Differentiation | |
dc.description.volume | 28 | |
dc.description.issue | 11 | |
dc.description.page | 3022-3035 | |
Appears in Collections: | Elements Staff Publications |
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