Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.carbpol.2021.118491
Title: Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression
Authors: Ashrafizadeh, Milad
Mirzaei, Sepideh
Gholami, Mohammad Hossein
Hashemi, Farid
Zabolian, Amirhossein
Raei, Mehdi
Hushmandi, Kiavash
Zarrabi, Ali
Voelcker, Nicolas H.
Aref, Amir Reza
Hamblin, Michael R.
Varma, Rajender S.
Samarghandian, Saeed
Arostegi, I. J.
Alzola, M.
Kumar, Alan Prem 
Thakur, Vijay Kumar
Nabavi, Noushin
Makvandi, Pooyan
Tay, Franklin R.
Orive, Gorka
Keywords: CD44
Doxorubicin
Drug resistance
Endocytosis
Hyaluronic acid
Nanodelivery system
Theranostic
Issue Date: 1-Nov-2021
Publisher: Elsevier Ltd
Citation: Ashrafizadeh, Milad, Mirzaei, Sepideh, Gholami, Mohammad Hossein, Hashemi, Farid, Zabolian, Amirhossein, Raei, Mehdi, Hushmandi, Kiavash, Zarrabi, Ali, Voelcker, Nicolas H., Aref, Amir Reza, Hamblin, Michael R., Varma, Rajender S., Samarghandian, Saeed, Arostegi, I. J., Alzola, M., Kumar, Alan Prem, Thakur, Vijay Kumar, Nabavi, Noushin, Makvandi, Pooyan, Tay, Franklin R., Orive, Gorka (2021-11-01). Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression. Carbohydrate Polymers 272 : 118491. ScholarBank@NUS Repository. https://doi.org/10.1016/j.carbpol.2021.118491
Rights: Attribution 4.0 International
Abstract: An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed. © 2021 The Author(s)
Source Title: Carbohydrate Polymers
URI: https://scholarbank.nus.edu.sg/handle/10635/233287
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2021.118491
Rights: Attribution 4.0 International
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